FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003117646> ?p ?o ?g. }

• W2003117646 endingPage "11" @default.
• W2003117646 startingPage "1" @default.
• W2003117646 abstract "Glomerular mesangial cells (MC), like most cell types secrete hyaluronan (HA), which attached to the cell surface via CD44, is the backbone of a hydrophilic gel matrix around these cells. Reduced extracellular matrix thickness and viscosity result from HA cleavage during inflammation. HA fragments were reported to trigger innate immunity via Toll-like receptor-(TLR-) 2 and/or TLR4 in immune cells. We questioned whether HA fragments also regulate the immunostimulatory capacity of smooth muscle cell-like MC. LPS (TLR4-ligand) and PAM3CysSK4 (TLR2-ligand) induced IL-6 secretion in MC; highly purified endotoxin-free HA<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mo><</mml:mo></mml:mrow></mml:math>3000 Da up to 50 μ g/mL did not. Bovine-testis-hyaluronidase from was used to digest MC-HA into HA fragments of different size directly in the cell culture. Resultant HA fragments did not activate TLR4-deficient MC, while TLR2-deficient MC responded to LPS-contamination of hyaluronidase, not to produced HA fragments. Hyaluronidase increased the stimulatory effect of TLR2-/-3/-5 ligands on their TLR-receptors in TLR4-deficient MC, excluding any effect by LPS-contamination. Supplemented heparin suppressed every stimulatory effect in a dose-dependent manner. We conclude that the glycosaminoglycan HA creates a pericellular jelly barrier, which covers surface receptors like the TLRs. Barrier-thickness and viscosity balanced by HA-synthesis and degradation and the amount of HA-receptors on the cell surface regulate innate immunity via the accessibility of the receptors." @default.
• W2003117646 created "2016-06-24" @default.
• W2003117646 creator A5010478903 @default.
• W2003117646 creator A5031071023 @default.
• W2003117646 creator A5067198984 @default.
• W2003117646 date "2014-01-21" @default.
• W2003117646 modified "2023-10-11" @default.
• W2003117646 title "Hyaluronan Is Not a Ligand but a Regulator of Toll-Like Receptor Signaling in Mesangial Cells: Role of Extracellular Matrix in Innate Immunity" @default.
• W2003117646 cites W1502415301 @default.
• W2003117646 cites W1554199252 @default.
• W2003117646 cites W1568165627 @default.
• W2003117646 cites W1907274918 @default.
• W2003117646 cites W1973769178 @default.
• W2003117646 cites W1981589473 @default.
• W2003117646 cites W1994496207 @default.
• W2003117646 cites W2003380614 @default.
• W2003117646 cites W2013288304 @default.
• W2003117646 cites W2016741118 @default.
• W2003117646 cites W2018372725 @default.
• W2003117646 cites W2037797688 @default.
• W2003117646 cites W2038692722 @default.
• W2003117646 cites W2042433863 @default.
• W2003117646 cites W2049874360 @default.
• W2003117646 cites W2053390181 @default.
• W2003117646 cites W2053566118 @default.
• W2003117646 cites W2054975287 @default.
• W2003117646 cites W2075933971 @default.
• W2003117646 cites W2087369502 @default.
• W2003117646 cites W2092458525 @default.
• W2003117646 cites W2092733738 @default.
• W2003117646 cites W2094463157 @default.
• W2003117646 cites W2097372881 @default.
• W2003117646 cites W2097847761 @default.
• W2003117646 cites W2098690568 @default.
• W2003117646 cites W2099390064 @default.
• W2003117646 cites W2100090670 @default.
• W2003117646 cites W2101436827 @default.
• W2003117646 cites W2101842736 @default.
• W2003117646 cites W2115850341 @default.
• W2003117646 cites W2118612850 @default.
• W2003117646 cites W2126626660 @default.
• W2003117646 cites W2126659405 @default.
• W2003117646 cites W2130989367 @default.
• W2003117646 cites W2133520153 @default.
• W2003117646 cites W2144032514 @default.
• W2003117646 cites W2150895961 @default.
• W2003117646 cites W2159950382 @default.
• W2003117646 cites W2170697062 @default.
• W2003117646 cites W4231687446 @default.
• W2003117646 doi "https://doi.org/10.1155/2014/714081" @default.
• W2003117646 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4045461" @default.
• W2003117646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24967246" @default.
• W2003117646 hasPublicationYear "2014" @default.
• W2003117646 type Work @default.
• W2003117646 sameAs 2003117646 @default.
• W2003117646 citedByCount "41" @default.
• W2003117646 countsByYear W20031176462014 @default.
• W2003117646 countsByYear W20031176462015 @default.
• W2003117646 countsByYear W20031176462016 @default.
• W2003117646 countsByYear W20031176462017 @default.
• W2003117646 countsByYear W20031176462018 @default.
• W2003117646 countsByYear W20031176462019 @default.
• W2003117646 countsByYear W20031176462020 @default.
• W2003117646 countsByYear W20031176462021 @default.
• W2003117646 countsByYear W20031176462022 @default.
• W2003117646 countsByYear W20031176462023 @default.
• W2003117646 crossrefType "journal-article" @default.
• W2003117646 hasAuthorship W2003117646A5010478903 @default.
• W2003117646 hasAuthorship W2003117646A5031071023 @default.
• W2003117646 hasAuthorship W2003117646A5067198984 @default.
• W2003117646 hasBestOaLocation W20031176461 @default.
• W2003117646 hasConcept C136449434 @default.
• W2003117646 hasConcept C153911025 @default.
• W2003117646 hasConcept C170493617 @default.
• W2003117646 hasConcept C185592680 @default.
• W2003117646 hasConcept C189165786 @default.
• W2003117646 hasConcept C193419808 @default.
• W2003117646 hasConcept C203014093 @default.
• W2003117646 hasConcept C2776070231 @default.
• W2003117646 hasConcept C2776709828 @default.
• W2003117646 hasConcept C2781236682 @default.
• W2003117646 hasConcept C55493867 @default.
• W2003117646 hasConcept C86803240 @default.
• W2003117646 hasConcept C8891405 @default.
• W2003117646 hasConcept C95444343 @default.
• W2003117646 hasConceptScore W2003117646C136449434 @default.
• W2003117646 hasConceptScore W2003117646C153911025 @default.
• W2003117646 hasConceptScore W2003117646C170493617 @default.
• W2003117646 hasConceptScore W2003117646C185592680 @default.
• W2003117646 hasConceptScore W2003117646C189165786 @default.
• W2003117646 hasConceptScore W2003117646C193419808 @default.
• W2003117646 hasConceptScore W2003117646C203014093 @default.
• W2003117646 hasConceptScore W2003117646C2776070231 @default.
• W2003117646 hasConceptScore W2003117646C2776709828 @default.
• W2003117646 hasConceptScore W2003117646C2781236682 @default.
• W2003117646 hasConceptScore W2003117646C55493867 @default.
• W2003117646 hasConceptScore W2003117646C86803240 @default.
• W2003117646 hasConceptScore W2003117646C8891405 @default.

• next