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• W2003118082 abstract "A mathematical model is presented that describes the health-endangering interaction of fibrous particles deposited in the human alveoli with alveolar fluids, cells, and tissues. As suggested by the theoretical approach, short fibers (diameter: 0.5 μm, length: 2-10 μm) are preferably ingested by alveolar macrophages and removed from the alveolar surface 10-15 days after exposure. Long (diameter: 0.5 μm, length: 10-50 μm) biopersistent fibers are not effectively cleared from the alveoli due to the repeated process of frustrated phagocytosis. Long biosoluble fibers also undergo a frustrated phagocytosis, with processes of extensive lysis leading to their significant shortening. The decrease in length causes the initiation of those clearance mechanisms that are efficient for short fibers." @default.
• W2003118082 created "2016-06-24" @default.
• W2003118082 creator A5091893852 @default.
• W2003118082 date "2011-07-01" @default.
• W2003118082 modified "2023-09-27" @default.
• W2003118082 title "A computer model for the simulation of fiber–cell interaction in the alveolar region of the respiratory tract" @default.
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• W2003118082 doi "https://doi.org/10.1016/j.compbiomed.2011.05.009" @default.
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