FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003127955> ?p ?o ?g. }

• W2003127955 endingPage "20133" @default.
• W2003127955 startingPage "20128" @default.
• W2003127955 abstract "The neural protein Fe65 possesses three putative protein-protein interaction domains: one WW domain and two phosphotyrosine interaction/phosphotyrosine binding domains (PID1 and PID2); the most C-terminal of these domains (PID2) interacts in vivo with the Alzheimer's beta-amyloid precursor protein, whereas the WW domain binds to Mena, the mammalian homolog of Drosophila-enabled protein. By the interaction trap procedure, we isolated a cDNA clone encoding a possible ligand of the N-terminal PID/PTB domain of Fe65 (PID1). Sequence analysis of this clone revealed that this ligand corresponded to the previously identified transcription factor CP2/LSF/LBP1. Co-immunoprecipitation experiments demonstrated that the interaction between Fe65 and CP2/LSF/LBP1 also takes place in vivo between the native molecules. The localization of both proteins was studied using fractionated cellular extracts. These experiments demonstrated that the various isoforms of CP2/LSF/LBP1 are differently distributed among subcellular fractions. At least one isoform, derived from alternative splicing (LSF-ID), is present outside the nucleus; Fe65 was found in both fractions. Furthermore, transfection experiments with an HA-tagged CP2/LSF/LBP1 cDNA demonstrated that Fe65 interacts also with the nuclear form of CP2/LSF/LBP1. Considering that the analysis of Fe65 distribution in fractionated cell extracts demonstrated that this protein is present both in nuclear and non-nuclear fractions, we examined the expression of Fe65 deletion mutants in the two fractions. This analysis allowed us to observe that a small region N-terminal to the WW domain is phosphorylated and is necessary for the presence of Fe65 in the nuclear fraction." @default.
• W2003127955 created "2016-06-24" @default.
• W2003127955 creator A5001436978 @default.
• W2003127955 creator A5054781081 @default.
• W2003127955 creator A5056961111 @default.
• W2003127955 creator A5087868901 @default.
• W2003127955 date "1998-08-01" @default.
• W2003127955 modified "2023-10-18" @default.
• W2003127955 title "The Fe65 Adaptor Protein Interacts through Its PID1 Domain with the Transcription Factor CP2/LSF/LBP1" @default.
• W2003127955 cites W1528281043 @default.
• W2003127955 cites W1600808722 @default.
• W2003127955 cites W1801937054 @default.
• W2003127955 cites W1967237003 @default.
• W2003127955 cites W1971227936 @default.
• W2003127955 cites W1977186059 @default.
• W2003127955 cites W1979991273 @default.
• W2003127955 cites W1980288440 @default.
• W2003127955 cites W1981008691 @default.
• W2003127955 cites W1988626042 @default.
• W2003127955 cites W2005397075 @default.
• W2003127955 cites W2016777985 @default.
• W2003127955 cites W2019070778 @default.
• W2003127955 cites W2023352519 @default.
• W2003127955 cites W2029205666 @default.
• W2003127955 cites W2031287920 @default.
• W2003127955 cites W2032952059 @default.
• W2003127955 cites W2032975373 @default.
• W2003127955 cites W2037358762 @default.
• W2003127955 cites W2038491728 @default.
• W2003127955 cites W2039750814 @default.
• W2003127955 cites W2044585914 @default.
• W2003127955 cites W2044735117 @default.
• W2003127955 cites W2051314670 @default.
• W2003127955 cites W2062876006 @default.
• W2003127955 cites W2082669967 @default.
• W2003127955 cites W2087496042 @default.
• W2003127955 cites W2090217559 @default.
• W2003127955 cites W2099667797 @default.
• W2003127955 cites W2106329420 @default.
• W2003127955 cites W2112327624 @default.
• W2003127955 cites W2124030177 @default.
• W2003127955 cites W2128039270 @default.
• W2003127955 cites W2129280965 @default.
• W2003127955 cites W2136653849 @default.
• W2003127955 cites W2150295206 @default.
• W2003127955 cites W2162051767 @default.
• W2003127955 cites W2170767109 @default.
• W2003127955 cites W2408690689 @default.
• W2003127955 doi "https://doi.org/10.1074/jbc.273.32.20128" @default.
• W2003127955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9685356" @default.
• W2003127955 hasPublicationYear "1998" @default.
• W2003127955 type Work @default.
• W2003127955 sameAs 2003127955 @default.
• W2003127955 citedByCount "144" @default.
• W2003127955 countsByYear W20031279552012 @default.
• W2003127955 countsByYear W20031279552013 @default.
• W2003127955 countsByYear W20031279552014 @default.
• W2003127955 countsByYear W20031279552015 @default.
• W2003127955 countsByYear W20031279552016 @default.
• W2003127955 countsByYear W20031279552017 @default.
• W2003127955 countsByYear W20031279552021 @default.
• W2003127955 crossrefType "journal-article" @default.
• W2003127955 hasAuthorship W2003127955A5001436978 @default.
• W2003127955 hasAuthorship W2003127955A5054781081 @default.
• W2003127955 hasAuthorship W2003127955A5056961111 @default.
• W2003127955 hasAuthorship W2003127955A5087868901 @default.
• W2003127955 hasBestOaLocation W20031279551 @default.
• W2003127955 hasConcept C104317684 @default.
• W2003127955 hasConcept C11804247 @default.
• W2003127955 hasConcept C153911025 @default.
• W2003127955 hasConcept C183786373 @default.
• W2003127955 hasConcept C187882448 @default.
• W2003127955 hasConcept C204491159 @default.
• W2003127955 hasConcept C2780114586 @default.
• W2003127955 hasConcept C2780723820 @default.
• W2003127955 hasConcept C29512474 @default.
• W2003127955 hasConcept C49805395 @default.
• W2003127955 hasConcept C53345823 @default.
• W2003127955 hasConcept C54458228 @default.
• W2003127955 hasConcept C54757728 @default.
• W2003127955 hasConcept C55493867 @default.
• W2003127955 hasConcept C62478195 @default.
• W2003127955 hasConcept C67705224 @default.
• W2003127955 hasConcept C71829478 @default.
• W2003127955 hasConcept C86339819 @default.
• W2003127955 hasConcept C86803240 @default.
• W2003127955 hasConcept C95444343 @default.
• W2003127955 hasConceptScore W2003127955C104317684 @default.
• W2003127955 hasConceptScore W2003127955C11804247 @default.
• W2003127955 hasConceptScore W2003127955C153911025 @default.
• W2003127955 hasConceptScore W2003127955C183786373 @default.
• W2003127955 hasConceptScore W2003127955C187882448 @default.
• W2003127955 hasConceptScore W2003127955C204491159 @default.
• W2003127955 hasConceptScore W2003127955C2780114586 @default.
• W2003127955 hasConceptScore W2003127955C2780723820 @default.
• W2003127955 hasConceptScore W2003127955C29512474 @default.
• W2003127955 hasConceptScore W2003127955C49805395 @default.
• W2003127955 hasConceptScore W2003127955C53345823 @default.

• next