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- W2003130016 abstract "Neosurugatoxin, a neurotoxin isolated from the Japanese ivory mollusc (Babylonia japonica) is a nicotinic antagonist with a specificity towards ganglionic nicotinic receptors. At low concentration (5 × 10−8 M) neosurugatoxin inhibited the release of [3H]dopamine evoked by 1,1-dimethyl-4-phenylpiperazinium (DMPP) from rat striatal nerve terminals, without affecting the response to K+-depolarisation. In contrast, αbungarotoxin did not antagonise the action of DMPP. Neosurugatoxin also inhibited [3H] nicotine binding to rat brain membranes but had no effect on [125I]αbungarotoxin binding to the same tissue preparation. These results support the view that functional nicotinic receptors in the CNS resemble ganglionic nicotinic receptors. Neosurugatoxin has considerable potential as a useful probe for such receptors in the brain." @default.
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- W2003130016 date "1985-01-01" @default.
- W2003130016 modified "2023-10-14" @default.
- W2003130016 title "Neosurugatoxin blocks nicotinic acetylcholine receptors in the brain" @default.
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- W2003130016 doi "https://doi.org/10.1016/0197-0186(85)90131-7" @default.
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