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- W2003131026 abstract "We have sequenced the heavy and light chain genes from 365 IgG+ B cells and found that 24 (6.5 %) contain somatically introduced insertions or deletions. These insertions and deletions are clustered at “hot-spots” in the antigen-binding site and frequently result in the creation of new combinations of canonical loop structures or entirely new loops that are not present in the human germline repertoire, but are similar to those seen in other species. Somatic insertion and deletion therefore provides a further mechanism for introducing structural diversity into antibodies in addition to somatic point mutation and receptor editing, which have small (single amino acid changes) and large (chain replacement) impacts on structural diversity, respectively." @default.
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- W2003131026 date "1999-12-01" @default.
- W2003131026 modified "2023-10-12" @default.
- W2003131026 title "Somatic insertions and deletions shape the human antibody repertoire 1 1Edited by J. Karn" @default.
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- W2003131026 doi "https://doi.org/10.1006/jmbi.1999.3289" @default.
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