FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003132649> ?p ?o ?g. }

• W2003132649 endingPage "e2475" @default.
• W2003132649 startingPage "e2475" @default.
• W2003132649 abstract "Background Pancreatic cancer cells generate metastases because they can survive the stress imposed by the new environment of the host tissue. To mimic this process, pancreatic cancer cells which are not stressed in standard culture conditions are injected into nude mice. Because they develop xenografts, they should have developed adequate stress response. Characterizing that response might provide new strategies to interfere with pancreatic cancer metastasis. Methodology/Principal Findings In the human pancreatic cancer cell lines Panc-1, Mia-PaCa2, Capan-1, Capan-2 and BxPC3, we used Affymetrix DNA microarrays to compare the expressions of 22.000 genes in vitro and in the corresponding xenografts. We identified 228 genes overexpressed in xenografts and characterized the implication of one of them, WSB1, in the control of apoptosis and cell proliferation. WSB1 generates 3 alternatively spliced transcripts encoding distinct protein isoforms. In xenografts and in human pancreatic tumors, global expression of WSB1 mRNA is modestly increased whereas isoform 3 is strongly overexpressed and isoforms 1 and 2 are down-regulated. Treating Mia-PaCa2 cells with stress-inducing agents induced similar changes. Whereas retrovirus-forced expression of WSB1 isoforms 1 and 2 promoted cell growth and sensitized the cells to gemcitabine- and doxorubicin-induced apoptosis, WSB1 isoform 3 expression reduced cell proliferation and enhanced resistance to apoptosis, showing that stress-induced modulation of WSB1 alternative splicing increases resistance to apoptosis of pancreatic cancer cells. Conclusions/Significance Data on WSB1 regulation support the hypothesis that activation of stress-response mechanisms helps cancer cells establishing metastases and suggest relevance to cancer development of other genes overexpressed in xenografts." @default.
• W2003132649 created "2016-06-24" @default.
• W2003132649 creator A5029085609 @default.
• W2003132649 creator A5030527739 @default.
• W2003132649 creator A5053807097 @default.
• W2003132649 creator A5058614093 @default.
• W2003132649 creator A5066948009 @default.
• W2003132649 creator A5073328006 @default.
• W2003132649 creator A5081556974 @default.
• W2003132649 date "2008-06-25" @default.
• W2003132649 modified "2023-09-26" @default.
• W2003132649 title "The WSB1 Gene Is Involved in Pancreatic Cancer Progression" @default.
• W2003132649 cites W1981321743 @default.
• W2003132649 cites W1982162547 @default.
• W2003132649 cites W2024675721 @default.
• W2003132649 cites W2025970479 @default.
• W2003132649 cites W2027530263 @default.
• W2003132649 cites W2038223966 @default.
• W2003132649 cites W2073669361 @default.
• W2003132649 cites W2109694492 @default.
• W2003132649 cites W2116062045 @default.
• W2003132649 cites W2126517526 @default.
• W2003132649 cites W2156466598 @default.
• W2003132649 cites W2324224266 @default.
• W2003132649 cites W4247785462 @default.
• W2003132649 cites W43051898 @default.
• W2003132649 cites W4361773609 @default.
• W2003132649 cites W47448073 @default.
• W2003132649 doi "https://doi.org/10.1371/journal.pone.0002475" @default.
• W2003132649 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2423480" @default.
• W2003132649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18575577" @default.
• W2003132649 hasPublicationYear "2008" @default.
• W2003132649 type Work @default.
• W2003132649 sameAs 2003132649 @default.
• W2003132649 citedByCount "29" @default.
• W2003132649 countsByYear W20031326492012 @default.
• W2003132649 countsByYear W20031326492014 @default.
• W2003132649 countsByYear W20031326492015 @default.
• W2003132649 countsByYear W20031326492016 @default.
• W2003132649 countsByYear W20031326492017 @default.
• W2003132649 countsByYear W20031326492018 @default.
• W2003132649 countsByYear W20031326492019 @default.
• W2003132649 countsByYear W20031326492020 @default.
• W2003132649 countsByYear W20031326492021 @default.
• W2003132649 countsByYear W20031326492022 @default.
• W2003132649 countsByYear W20031326492023 @default.
• W2003132649 crossrefType "journal-article" @default.
• W2003132649 hasAuthorship W2003132649A5029085609 @default.
• W2003132649 hasAuthorship W2003132649A5030527739 @default.
• W2003132649 hasAuthorship W2003132649A5053807097 @default.
• W2003132649 hasAuthorship W2003132649A5058614093 @default.
• W2003132649 hasAuthorship W2003132649A5066948009 @default.
• W2003132649 hasAuthorship W2003132649A5073328006 @default.
• W2003132649 hasAuthorship W2003132649A5081556974 @default.
• W2003132649 hasBestOaLocation W20031326491 @default.
• W2003132649 hasConcept C104317684 @default.
• W2003132649 hasConcept C121608353 @default.
• W2003132649 hasConcept C150194340 @default.
• W2003132649 hasConcept C153911025 @default.
• W2003132649 hasConcept C190283241 @default.
• W2003132649 hasConcept C194583182 @default.
• W2003132649 hasConcept C2779013556 @default.
• W2003132649 hasConcept C2780210213 @default.
• W2003132649 hasConcept C502942594 @default.
• W2003132649 hasConcept C53345823 @default.
• W2003132649 hasConcept C54355233 @default.
• W2003132649 hasConcept C81885089 @default.
• W2003132649 hasConcept C8415881 @default.
• W2003132649 hasConcept C86803240 @default.
• W2003132649 hasConcept C96232424 @default.
• W2003132649 hasConceptScore W2003132649C104317684 @default.
• W2003132649 hasConceptScore W2003132649C121608353 @default.
• W2003132649 hasConceptScore W2003132649C150194340 @default.
• W2003132649 hasConceptScore W2003132649C153911025 @default.
• W2003132649 hasConceptScore W2003132649C190283241 @default.
• W2003132649 hasConceptScore W2003132649C194583182 @default.
• W2003132649 hasConceptScore W2003132649C2779013556 @default.
• W2003132649 hasConceptScore W2003132649C2780210213 @default.
• W2003132649 hasConceptScore W2003132649C502942594 @default.
• W2003132649 hasConceptScore W2003132649C53345823 @default.
• W2003132649 hasConceptScore W2003132649C54355233 @default.
• W2003132649 hasConceptScore W2003132649C81885089 @default.
• W2003132649 hasConceptScore W2003132649C8415881 @default.
• W2003132649 hasConceptScore W2003132649C86803240 @default.
• W2003132649 hasConceptScore W2003132649C96232424 @default.
• W2003132649 hasIssue "6" @default.
• W2003132649 hasLocation W20031326491 @default.
• W2003132649 hasLocation W20031326492 @default.
• W2003132649 hasLocation W20031326493 @default.
• W2003132649 hasLocation W20031326494 @default.
• W2003132649 hasLocation W20031326495 @default.
• W2003132649 hasOpenAccess W2003132649 @default.
• W2003132649 hasPrimaryLocation W20031326491 @default.
• W2003132649 hasRelatedWork W2043890160 @default.
• W2003132649 hasRelatedWork W2337680646 @default.
• W2003132649 hasRelatedWork W2386605958 @default.
• W2003132649 hasRelatedWork W2501960686 @default.
• W2003132649 hasRelatedWork W2582912872 @default.

• next