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• W2003133214 abstract "Recently, fungal elements were suspected to be the causative agent of chronic rhinosinusitis, and benefits of topical amphotericin B therapy have been reported.The effects of amphotericin B versus control nasal spray on chronic rhinosinusitis were compared in a double-blind, randomized clinical trial.Patients with chronic rhinosinusitis were administered 200 microL per nostril amphotericin B (3 mg/mL) or saline nasal spray 4 times daily over a period of 8 weeks. The response rate, defined as a 50% reduction of pretreatment computed tomography score, was the primary outcome variable. Additional outcome variables included a symptom score, a quality of life score, and an endoscopy score. Before and after treatment, nasal lavages were pretreated with dithiothreitol and examined for fungal elements by PCR and standard culture techniques.Seventy-eight patients were included, and 60 patients finished the study per protocol. In the control group, no positive response (0 of 32) was observed, and 2 of 28 patients responded in the amphotericin B group (P>.2). The symptom scores were distinctly worse after amphotericin B therapy (P <.005). The other parameters investigated did not differ remarkably between the treatment groups.Nasal amphotericin B spray in the described dosing and time schedule is ineffective and deteriorates patient symptoms." @default.
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• W2003133214 date "2004-06-01" @default.
• W2003133214 modified "2023-10-18" @default.
• W2003133214 title "Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: A randomized, double-blind clinical trial" @default.
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• W2003133214 doi "https://doi.org/10.1016/j.jaci.2004.03.038" @default.
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