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• W2003133544 abstract "Objective: To determine whether estrogen down-regulates MCP-1 in vascular endothelial cells.Design: A prospective comparative study.Setting: Academic research environment.Patient(s): Human umbilical vein endothelial cells (n = 3) and human coronary artery endothelial cells (n = 3) obtained from females.Intervention(s): Human umbilical vein endothelial cells (HUVEC) and human coronary artery endothelial cells (HCAEC) were grown to preconfluence. Then, they were treated with various concentrations of estradiol (10−11 M to 10−7 M) as well as raloxifene (10−7 M) and tamoxifen (10−7 M). MCP-1 in culture media was quantified using an enzyme-linked immunosorbent assay (ELISA). Cellular ribonucleic acid (RNA) was extracted and Northern blots were hybridized with an oligonucleotide probe complementary to a specific sequence of MCP-1 mRNA.Main Outcome Measure(s): MCP-1 protein and mRNA.Result(s): Estrogen treatment did not change MCP-1 expression in HUVEC. On the other hand, in HCAEC, estradiol induced a 30% decrease in mRNA expression and resulted in dose-dependent inhibition of MCP-1 production as detected by ELISA. Raloxifene and tamoxifen also resulted in inhibition of MCP-1 mRNA and protein expression.Conclusion(s): Our findings suggest that one of the mechanisms by which estrogen down-regulates atherosclerosis is by suppressing vascular MCP-1 expression, resulting in decreased macrophage recruitment." @default.
• W2003133544 created "2016-06-24" @default.
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• W2003133544 date "2002-03-01" @default.
• W2003133544 modified "2023-10-07" @default.
• W2003133544 title "Estradiol down-regulates MCP-1 expression in human coronary artery endothelial cells" @default.
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• W2003133544 doi "https://doi.org/10.1016/s0015-0282(01)03223-x" @default.
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