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- W200313450 abstract "This chapter focuses on insulin and liver. The liver has a central role in metabolic regulation. It can form glycogen from glucose and it can synthesize glucose from three carbon precursors or glycogen and liberate it into the blood; it can synthesize fatty acids from carbohydrate or amino acid moieties, or break down the fatty acids reaching it from peripheral adipose tissue into ketone bodies; it can synthesize protein or degrade it to precursors of carbohydrate or fatty acids; and perhaps most important of all, it undergoes, in response to hormones, changes in the enzymatic machinery which carries out these processes. In the severe diabetic, there is evidence of failure of normal liver function, particularly with respect to synthesis and breakdown of fat. Administration of insulin to such animals allows repair of the hepatic deficiencies, this correction requiring some hours. Direct stimulation of fatty acid synthesis in normal rat liver slices and of amino acid incorporation into protein in mildly diabetic rat livers have been obtained." @default.
- W200313450 created "2016-06-24" @default.
- W200313450 creator A5047423886 @default.
- W200313450 date "1961-01-01" @default.
- W200313450 modified "2023-10-18" @default.
- W200313450 title "Insulin and the Liver" @default.
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- W200313450 doi "https://doi.org/10.1016/b978-1-4832-3285-0.50007-x" @default.
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