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• W2003135080 abstract "Purpose: Microfracture is a well-established procedure in cartilage knee surgery. Currently there are many different techniques utilizing biological implants to support the chondrogenesis. The purpose of this study is to evaluate the medium-term results of the hyaluronic scaffold in combination with fresh bone marrow transplantation or with microfractures in treatment of cartilage defects of the knee joint. Methods: A new type of hyaluronic acid membrane Hyalofast (Anika Therapeutics, Inc. MA, USA) was used as a CHONDROINDUCTIVE SCAFFOLD that allows attachment and stimulation of mesenchymal stem cells of bone marrow. In study group we used hyaluronan scaffold with fresh bone marrow transplantation and in control group the scaffold was combined with microfractures. Patients were followed using a Socrates Orthopeadic Outcome Software (Ortholink Pty Ltd, Australia) database tool to track changes in function and symptoms by the Lysholm, Tegner and VAS scores along with MRI imaging. Results: 40 Patients met the inclusion criteria for this study. Both groups consisted of 20 patients. All defects was grade IIIA (n = 10) and IIIB (n = 20) according to the ICRS classification. The mean defect size of the chondral lesions was 2.7 cm (2) (range 1,4–3,1). Defects were localized at the medial (n = 12) and lateral (n = 8) condyle, at the trochlea (n = 12) and at the patella = (8). Based on the imaging evaluation a satisfactory outcome was observed in all cases at estimated intervals. Significant improvement (P = 0,002, wilcoxon rank-sum test) was observed in Lysholm (preop = 61,2 ; 1 year postop = 82,3; 2 year postop = 85,3) Tegner improvement (2,7) and VAS scores. All patients returned to sport activities which they performed before the surgery. No adverse effects related to the implant were observed during the duration of the study. There was no statisctical difference (p = 0,08) in the results between both groups. Conclusions: The use of hyaluronic acid membrane is considered to be safe and effective procedure for treatment of symptomatic chondral defects of the knee. The data shows that there is no difference between two techniques of utilizing mircofractues or bone marrow transplantation at the defect site. However, further studies with long-term follow-up are needed to determine if the grafted area will maintain structural and functional integrity over time." @default.
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• W2003135080 date "2014-04-01" @default.
• W2003135080 modified "2023-09-23" @default.
• W2003135080 title "Use of hyaluronan scaffold in combination with fresh bone marrow transplantation or with microfractures in treatment of cartilage defects of the knee joint" @default.
• W2003135080 doi "https://doi.org/10.1016/j.joca.2014.02.283" @default.
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