FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003135973> ?p ?o ?g. }

• W2003135973 endingPage "1017" @default.
• W2003135973 startingPage "1010" @default.
• W2003135973 abstract "Abstract Adaptive immunity is triggered at the immune synapse, where peptide-major histocompatibility complexes and costimulatory molecules expressed by dendritic cells (DCs) are physically presented to T cells. Here we describe transmission of the inflammatory monoamine serotonin (5-hydroxytryptamine [5-HT]) between these cells. DCs take up 5-HT from the microenvironment and from activated T cells (that synthesize 5-HT) and this uptake is inhibited by the antidepressant, fluoxetine. Expression of 5-HT transporters (SERTs) is regulated by DC maturation, exposure to microbial stimuli, and physical interactions with T cells. Significantly, 5-HT sequestered by DCs is stored within LAMP-1+ vesicles and subsequently released via Ca2+-dependent exocytosis, which was confirmed by amperometric recordings. In turn, extracellular 5-HT can reduce T-cell levels of cAMP, a modulator of T-cell activation. Thus, through the uptake of 5-HT at sites of inflammation, and from activated T cells, DCs may shuttle 5-HT to naive T cells and thereby modulate T-cell proliferation and differentiation. These data constitute the first direct measurement of triggered exocytosis by DCs and reveal a new and rapid type of signaling that may be optimized by the intimate synaptic environment between DCs and T cells. Moreover, these results highlight an important role for 5-HT signaling in immune function and the potential consequences of commonly used drugs that target 5-HT uptake and release." @default.
• W2003135973 created "2016-06-24" @default.
• W2003135973 creator A5016438781 @default.
• W2003135973 creator A5017371290 @default.
• W2003135973 creator A5033670721 @default.
• W2003135973 creator A5037853976 @default.
• W2003135973 creator A5061882696 @default.
• W2003135973 creator A5080151806 @default.
• W2003135973 date "2006-02-01" @default.
• W2003135973 modified "2023-10-17" @default.
• W2003135973 title "A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells" @default.
• W2003135973 cites W1517765711 @default.
• W2003135973 cites W1554937135 @default.
• W2003135973 cites W1564721318 @default.
• W2003135973 cites W1595217065 @default.
• W2003135973 cites W1624946627 @default.
• W2003135973 cites W1669165205 @default.
• W2003135973 cites W1958130795 @default.
• W2003135973 cites W1961232072 @default.
• W2003135973 cites W1976114760 @default.
• W2003135973 cites W1998670692 @default.
• W2003135973 cites W2008704486 @default.
• W2003135973 cites W2012129851 @default.
• W2003135973 cites W2017415762 @default.
• W2003135973 cites W2019286212 @default.
• W2003135973 cites W2021657931 @default.
• W2003135973 cites W2023952978 @default.
• W2003135973 cites W2035070093 @default.
• W2003135973 cites W2037920661 @default.
• W2003135973 cites W2049815306 @default.
• W2003135973 cites W2052986527 @default.
• W2003135973 cites W2056442885 @default.
• W2003135973 cites W2067065957 @default.
• W2003135973 cites W2069675539 @default.
• W2003135973 cites W2085036778 @default.
• W2003135973 cites W2090640877 @default.
• W2003135973 cites W2092157690 @default.
• W2003135973 cites W2092655681 @default.
• W2003135973 cites W2093567309 @default.
• W2003135973 cites W2098942777 @default.
• W2003135973 cites W2104685421 @default.
• W2003135973 cites W2126368883 @default.
• W2003135973 cites W2152857351 @default.
• W2003135973 cites W2154690985 @default.
• W2003135973 cites W2156831625 @default.
• W2003135973 cites W2163905724 @default.
• W2003135973 cites W2166676682 @default.
• W2003135973 cites W2166867959 @default.
• W2003135973 cites W2177327503 @default.
• W2003135973 cites W2354928181 @default.
• W2003135973 cites W4246342829 @default.
• W2003135973 cites W4323913445 @default.
• W2003135973 doi "https://doi.org/10.1182/blood-2005-07-2903" @default.
• W2003135973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1895901" @default.
• W2003135973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16223770" @default.
• W2003135973 hasPublicationYear "2006" @default.
• W2003135973 type Work @default.
• W2003135973 sameAs 2003135973 @default.
• W2003135973 citedByCount "192" @default.
• W2003135973 countsByYear W20031359732012 @default.
• W2003135973 countsByYear W20031359732013 @default.
• W2003135973 countsByYear W20031359732014 @default.
• W2003135973 countsByYear W20031359732015 @default.
• W2003135973 countsByYear W20031359732016 @default.
• W2003135973 countsByYear W20031359732017 @default.
• W2003135973 countsByYear W20031359732018 @default.
• W2003135973 countsByYear W20031359732019 @default.
• W2003135973 countsByYear W20031359732020 @default.
• W2003135973 countsByYear W20031359732021 @default.
• W2003135973 countsByYear W20031359732022 @default.
• W2003135973 countsByYear W20031359732023 @default.
• W2003135973 crossrefType "journal-article" @default.
• W2003135973 hasAuthorship W2003135973A5016438781 @default.
• W2003135973 hasAuthorship W2003135973A5017371290 @default.
• W2003135973 hasAuthorship W2003135973A5033670721 @default.
• W2003135973 hasAuthorship W2003135973A5037853976 @default.
• W2003135973 hasAuthorship W2003135973A5061882696 @default.
• W2003135973 hasAuthorship W2003135973A5080151806 @default.
• W2003135973 hasBestOaLocation W20031359731 @default.
• W2003135973 hasConcept C175969161 @default.
• W2003135973 hasConcept C185592680 @default.
• W2003135973 hasConcept C203014093 @default.
• W2003135973 hasConcept C2776090121 @default.
• W2003135973 hasConcept C2776914184 @default.
• W2003135973 hasConcept C2778170410 @default.
• W2003135973 hasConcept C49039625 @default.
• W2003135973 hasConcept C55493867 @default.
• W2003135973 hasConcept C67662055 @default.
• W2003135973 hasConcept C86803240 @default.
• W2003135973 hasConcept C8891405 @default.
• W2003135973 hasConcept C95444343 @default.
• W2003135973 hasConceptScore W2003135973C175969161 @default.
• W2003135973 hasConceptScore W2003135973C185592680 @default.
• W2003135973 hasConceptScore W2003135973C203014093 @default.
• W2003135973 hasConceptScore W2003135973C2776090121 @default.
• W2003135973 hasConceptScore W2003135973C2776914184 @default.
• W2003135973 hasConceptScore W2003135973C2778170410 @default.
• W2003135973 hasConceptScore W2003135973C49039625 @default.

• next