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• W2003141316 abstract "<b><i>Background/Aims:</i></b> Gentamicin pharmacokinetics have not been described in patients undergoing short-daily hemodialysis (SDHD). The aim of this study is to describe gentamicin pharmacokinetics and dialytic clearance (Cl_dial) in SDHD patients and simulate gentamicin exposure after six dosing regimens to help guide future dosing. <b><i>Methods:</i></b> Six anuric patients undergoing SDHD were enrolled. Patients received intravenous infusion of 2 mg/kg gentamicin on day 1 after the first HD session followed by HD sessions on days 2, 3, and 4. Blood samples for determination of gentamicin concentrations were serially collected. Gentamicin pharmacokinetic parameters and Cl_dial and interindividual variability terms (IIV) were estimated using NONMEM VII. Influence of patient weight on systemic clearance (Cl_s) and central volume of distribution (V_c) and influence of urea removal estimates on Cl_dial were assessed. The model was used to simulate gentamicin concentrations after six dosing regimens including pre- and postdialysis as well as daily and every-other-day dosing. <b><i>Results:</i></b> A two-compartment model with first-order elimination from central compartment described gentamicin pharmacokinetics. Population estimates for Cl_s and Cl_dial were 7.6 and 134 ml/min, respectively. Patient weight was statistically significantly associated with Cl_s and V_c. Predialysis every-other-day regimens were as effective (C_max ≥8 mg/l and AUC_{48 h} ≥140 mg·h/l) and less toxic (C_min <2 mg/l and AUC_{48 h} <240 mg·h/l) than postdialysis regimens. <b><i>Conclusions:</i></b> Estimated gentamicin Cl_dial is higher than previous estimates with thrice-weekly regimens. Predialysis every-other-day dosing may be recommended during SDHD." @default.
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• W2003141316 date "2012-01-01" @default.
• W2003141316 modified "2023-09-30" @default.
• W2003141316 title "Gentamicin Pharmacokinetics and Pharmacodynamics during Short-Daily Hemodialysis" @default.
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• W2003141316 doi "https://doi.org/10.1159/000339937" @default.
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