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- W2003145257 abstract "Seven derivatives of the antitumor alkaloid ellipticine were assayed for activity against murine leukaemia L1210 and for mutagenicity in Ames' Salmonella-microsomes test. Not only did the results show a complete lack of correlation between these two properties, but it was possible to choose a highly efficient analog which was completely devoid of mutagenic and hence, probably, carcinogenic effect. The lack of interaction of this product (2-methyl-9-hydroxyellipticinium acetate) with Cytochrome P-450 of hepatic monooxygenases prevents the formation of reactive intermediates and their subsequent binding to DNA. These data are discussed in view of the currently admitted mode of action of ellipticines i.e., intercalation in DNA and their therapeutic use." @default.
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- W2003145257 date "1978-01-01" @default.
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- W2003145257 title "Some antitumor derivatives of ellipticine deprived of mutagenic properties" @default.
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- W2003145257 doi "https://doi.org/10.1016/0009-2797(78)90086-8" @default.
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