FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003145631> ?p ?o ?g. }

• W2003145631 endingPage "1664" @default.
• W2003145631 startingPage "1656" @default.
• W2003145631 abstract "Objective: To compare two drug regimens to treat resistant hypertension. Methods: In a prospective, randomized, open blinded endpoint study, 167 patients with mean baseline daytime ambulatory blood pressure 135 mmHg or more and/or 85 mmHg or more, despite 4 weeks’ treatment with irbesartan 300 mg/day, hydrochlorothiazide 12.5 mg/day and amlodipine 5 mg/day, were randomized to sequential nephron blockade (group 1, n = 85) or sequential renin–angiotensin system blockade (group 2, n = 82). First, spironolactone 25 mg/day in group 1 or ramipril 5 mg/day in group 2 were added for 4 weeks. Treatment was increased at weeks 4, 8 or 10 if home blood pressure was 135 mmHg or more and/or 85 mmHg or more by sequentially administering furosemide 20 mg/day, furosemide 40 mg/day and amiloride 5 mg/day in group 1, or ramipril 10 mg/day, bisoprolol 5 mg/day and bisoprolol 10 mg/day in group 2. The primary endpoint was change in systolic daytime ambulatory blood pressure at week 12. Results: At week 12, the mean between-group difference in daytime ambulatory blood pressure was 10/4 mmHg (95% confidence interval: 7–14/2–7; P < 0.001/P = 0.0014) in favour of the group 1. The blood pressure goal (daytime ambulatory blood pressure <135/85 mmHg) was achieved in 58% in the group 1 and 20% in the group 2 (P < 0.0001). Discontinuation for drug-related adverse events was low (group 1, n = 7; group 2, n = 6). Conclusion: In patients with resistant hypertension, sequential nephron blockade induces a large and well tolerated reduction in blood pressure via a progressive increase in sodium depletion, and is more effective than sequential renin–angiotensin system blockade." @default.
• W2003145631 created "2016-06-24" @default.
• W2003145631 creator A5033477592 @default.
• W2003145631 creator A5059403921 @default.
• W2003145631 creator A5070371776 @default.
• W2003145631 creator A5073381613 @default.
• W2003145631 creator A5077449453 @default.
• W2003145631 creator A5087581609 @default.
• W2003145631 creator A5088275687 @default.
• W2003145631 creator A5088372894 @default.
• W2003145631 creator A5088444378 @default.
• W2003145631 date "2012-08-01" @default.
• W2003145631 modified "2023-10-18" @default.
• W2003145631 title "Sequential nephron blockade versus sequential renin–angiotensin system blockade in resistant hypertension" @default.
• W2003145631 cites W1481523571 @default.
• W2003145631 cites W1965309126 @default.
• W2003145631 cites W1967610947 @default.
• W2003145631 cites W1979954040 @default.
• W2003145631 cites W1988536563 @default.
• W2003145631 cites W2008163059 @default.
• W2003145631 cites W2013354239 @default.
• W2003145631 cites W2015926677 @default.
• W2003145631 cites W2016325418 @default.
• W2003145631 cites W2023340577 @default.
• W2003145631 cites W2026218403 @default.
• W2003145631 cites W2048092130 @default.
• W2003145631 cites W2063753451 @default.
• W2003145631 cites W2072785882 @default.
• W2003145631 cites W2079169944 @default.
• W2003145631 cites W2091488460 @default.
• W2003145631 cites W2091910125 @default.
• W2003145631 cites W2092430951 @default.
• W2003145631 cites W2100026171 @default.
• W2003145631 cites W2102036895 @default.
• W2003145631 cites W2122088193 @default.
• W2003145631 cites W2122915712 @default.
• W2003145631 cites W2135100154 @default.
• W2003145631 cites W2137405125 @default.
• W2003145631 cites W2143954917 @default.
• W2003145631 cites W2148447335 @default.
• W2003145631 cites W2150734413 @default.
• W2003145631 cites W2152798629 @default.
• W2003145631 cites W2160350069 @default.
• W2003145631 cites W2276153739 @default.
• W2003145631 doi "https://doi.org/10.1097/hjh.0b013e3283551e98" @default.
• W2003145631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22728905" @default.
• W2003145631 hasPublicationYear "2012" @default.
• W2003145631 type Work @default.
• W2003145631 sameAs 2003145631 @default.
• W2003145631 citedByCount "115" @default.
• W2003145631 countsByYear W20031456312012 @default.
• W2003145631 countsByYear W20031456312013 @default.
• W2003145631 countsByYear W20031456312014 @default.
• W2003145631 countsByYear W20031456312015 @default.
• W2003145631 countsByYear W20031456312016 @default.
• W2003145631 countsByYear W20031456312017 @default.
• W2003145631 countsByYear W20031456312018 @default.
• W2003145631 countsByYear W20031456312019 @default.
• W2003145631 countsByYear W20031456312020 @default.
• W2003145631 countsByYear W20031456312021 @default.
• W2003145631 countsByYear W20031456312022 @default.
• W2003145631 crossrefType "journal-article" @default.
• W2003145631 hasAuthorship W2003145631A5033477592 @default.
• W2003145631 hasAuthorship W2003145631A5059403921 @default.
• W2003145631 hasAuthorship W2003145631A5070371776 @default.
• W2003145631 hasAuthorship W2003145631A5073381613 @default.
• W2003145631 hasAuthorship W2003145631A5077449453 @default.
• W2003145631 hasAuthorship W2003145631A5087581609 @default.
• W2003145631 hasAuthorship W2003145631A5088275687 @default.
• W2003145631 hasAuthorship W2003145631A5088372894 @default.
• W2003145631 hasAuthorship W2003145631A5088444378 @default.
• W2003145631 hasConcept C126322002 @default.
• W2003145631 hasConcept C126894567 @default.
• W2003145631 hasConcept C138976137 @default.
• W2003145631 hasConcept C149323552 @default.
• W2003145631 hasConcept C198710026 @default.
• W2003145631 hasConcept C27016395 @default.
• W2003145631 hasConcept C2777097880 @default.
• W2003145631 hasConcept C2777880890 @default.
• W2003145631 hasConcept C2777955127 @default.
• W2003145631 hasConcept C2779670145 @default.
• W2003145631 hasConcept C2779766728 @default.
• W2003145631 hasConcept C2779888176 @default.
• W2003145631 hasConcept C2780361556 @default.
• W2003145631 hasConcept C42219234 @default.
• W2003145631 hasConcept C71924100 @default.
• W2003145631 hasConcept C84393581 @default.
• W2003145631 hasConceptScore W2003145631C126322002 @default.
• W2003145631 hasConceptScore W2003145631C126894567 @default.
• W2003145631 hasConceptScore W2003145631C138976137 @default.
• W2003145631 hasConceptScore W2003145631C149323552 @default.
• W2003145631 hasConceptScore W2003145631C198710026 @default.
• W2003145631 hasConceptScore W2003145631C27016395 @default.
• W2003145631 hasConceptScore W2003145631C2777097880 @default.
• W2003145631 hasConceptScore W2003145631C2777880890 @default.
• W2003145631 hasConceptScore W2003145631C2777955127 @default.
• W2003145631 hasConceptScore W2003145631C2779670145 @default.
• W2003145631 hasConceptScore W2003145631C2779766728 @default.

• next