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• W2003145767 endingPage "504" @default.
• W2003145767 startingPage "483" @default.
• W2003145767 abstract "The findings that early events during HIV-1 and SIV infection of Asian rhesus macaques dictate the levels of viremia and rate of disease progression prior to the establishment of mature and effective adaptive immune responses strongly suggest an important role for innate immune mechanisms. In addition, the fact that the major target of HIV and SIV during this period of acute infection is the gastrointestinal tissue suggests that whatever role the innate immune system plays must either directly and/or indirectly focus on the GI tract. The object of this article is to provide a general overview of the innate immune system with a focus on natural killer (NK) cells and their role in the pathogenesis of lentivirus infection. The studies summarized include our current understanding of the phenotypic heterogeneity, the putative functions ascribed to the subsets, the maturation/differentiation of NK cells, the mechanisms by which their function is mediated and regulated, the studies of these NK-cell subsets, with a focus on killer cell immunoglobulin-like receptors (KIRs) in nonhuman primates and humans, and finally, how HIV and SIV infection affects these NK cells in vivo. Clearly much has yet to be learnt on how the innate immune system influences the interaction between lentiviruses and the host within the GI tract, knowledge of which is reasoned to be critical for the formulation of effective vaccines against HIV-1." @default.
• W2003145767 created "2016-06-24" @default.
• W2003145767 creator A5009543374 @default.
• W2003145767 creator A5022414598 @default.
• W2003145767 creator A5035464797 @default.
• W2003145767 creator A5041092935 @default.
• W2003145767 date "2010-07-01" @default.
• W2003145767 modified "2023-10-17" @default.
• W2003145767 title "Innate immune natural killer cells and their role in HIV and SIV infection" @default.
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