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• W2003148204 abstract "Various derivatives of androst-4-ene-3, 17-dione derived from microbial transformation were evaluated as inhibitors of human placental aromatase. 14α-Hydroxyandrost-4-ene-3, 6, 17-trione was the most potent inhibitor showing a time-dependent, pseudo-first-order inactivation of aromatase in the presence of reduced nicotinamide adenine dinucleotide phosphate with apparent Ki of 1.3μM and Kinact of 0.23min-1. This compound also inhibited aromatase in rat ovary and suppressed serum estradiol levels in in vivo experiments." @default.
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• W2003148204 date "1990-01-01" @default.
• W2003148204 modified "2023-09-26" @default.
• W2003148204 title "14.ALPHA.-Hydroxyandrost-4-ene-3,6,17-trione as a mechanical-based irreversible inhibitor of estrogen biosynthesis." @default.
• W2003148204 doi "https://doi.org/10.1248/cpb.38.2834" @default.
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