FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003148432> ?p ?o ?g. }

• W2003148432 endingPage "1138" @default.
• W2003148432 startingPage "1129" @default.
• W2003148432 abstract "Narcolepsy is caused by selective loss of the orexin/hypocretin-producing neurons of the hypothalamus. For patients with narcolepsy, chronic sleepiness is often the most disabling symptom, but current therapies rarely normalize alertness and do not address the underlying orexin deficiency. We hypothesized that the sleepiness of narcolepsy would substantially improve if orexin signaling were restored in specific brain regions at appropriate times of day.We used gene therapy to restore orexin signaling in a mouse model of narcolepsy. In these Atx mice, expression of a toxic protein (ataxin-3) selectively kills the orexin neurons.To induce ectopic expression of the orexin neuropeptides, we microinjected an adeno-associated viral vector coding for prepro-orexin plus a red fluorescence protein (AAV-orexin) into the mediobasal hypothalamus of Atx and wild-type mice. Control mice received an AAV coding only for red fluorescence protein. Two weeks later, we recorded sleep/wake behavior, locomotor activity, and body temperature and examined the patterns of orexin expression.Atx mice rescued with AAV-orexin produced long bouts of wakefulness and had a normal diurnal pattern of arousal, with the longest bouts of wake and the highest amounts of locomotor activity in the first hours of the night. In addition, AAV-orexin improved the timing of rapid eye movement sleep and the consolidation of nonrapid eye movement sleep in Atx mice.These substantial improvements in sleepiness and other symptoms of narcolepsy demonstrate the effectiveness of orexin gene therapy in a mouse model of narcolepsy. Additional work is needed to optimize this approach, but in time, AAV-orexin could become a useful therapeutic option for patients with narcolepsy." @default.
• W2003148432 created "2016-06-24" @default.
• W2003148432 creator A5005536434 @default.
• W2003148432 creator A5006194428 @default.
• W2003148432 creator A5008766966 @default.
• W2003148432 creator A5017375737 @default.
• W2003148432 creator A5026915344 @default.
• W2003148432 creator A5030287146 @default.
• W2003148432 creator A5074653156 @default.
• W2003148432 creator A5089293072 @default.
• W2003148432 date "2013-08-01" @default.
• W2003148432 modified "2023-10-18" @default.
• W2003148432 title "Orexin Gene Therapy Restores the Timing and Maintenance of Wakefulness in Narcoleptic Mice" @default.
• W2003148432 cites W1519232679 @default.
• W2003148432 cites W1537142000 @default.
• W2003148432 cites W1553153115 @default.
• W2003148432 cites W169572948 @default.
• W2003148432 cites W1829186012 @default.
• W2003148432 cites W1900979097 @default.
• W2003148432 cites W1926588156 @default.
• W2003148432 cites W1967241835 @default.
• W2003148432 cites W1983298714 @default.
• W2003148432 cites W1998320303 @default.
• W2003148432 cites W2002936258 @default.
• W2003148432 cites W2011580879 @default.
• W2003148432 cites W2033531639 @default.
• W2003148432 cites W2033754833 @default.
• W2003148432 cites W2034860964 @default.
• W2003148432 cites W2047162457 @default.
• W2003148432 cites W2049082572 @default.
• W2003148432 cites W2050539574 @default.
• W2003148432 cites W2060212263 @default.
• W2003148432 cites W2061341260 @default.
• W2003148432 cites W2061886084 @default.
• W2003148432 cites W2063210874 @default.
• W2003148432 cites W2063854877 @default.
• W2003148432 cites W2068973973 @default.
• W2003148432 cites W2070371908 @default.
• W2003148432 cites W2072154498 @default.
• W2003148432 cites W2075405772 @default.
• W2003148432 cites W2077122940 @default.
• W2003148432 cites W2090985998 @default.
• W2003148432 cites W2093349190 @default.
• W2003148432 cites W2098202275 @default.
• W2003148432 cites W2110175860 @default.
• W2003148432 cites W2115070641 @default.
• W2003148432 cites W2119709085 @default.
• W2003148432 cites W2134923404 @default.
• W2003148432 cites W2135640564 @default.
• W2003148432 cites W2144249632 @default.
• W2003148432 cites W2154534807 @default.
• W2003148432 cites W2157226283 @default.
• W2003148432 cites W2157424197 @default.
• W2003148432 cites W2159953069 @default.
• W2003148432 cites W2167119018 @default.
• W2003148432 cites W2405993140 @default.
• W2003148432 cites W37427538 @default.
• W2003148432 cites W4296220318 @default.
• W2003148432 cites W4324114551 @default.
• W2003148432 doi "https://doi.org/10.5665/sleep.2870" @default.
• W2003148432 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3700709" @default.
• W2003148432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23904672" @default.
• W2003148432 hasPublicationYear "2013" @default.
• W2003148432 type Work @default.
• W2003148432 sameAs 2003148432 @default.
• W2003148432 citedByCount "48" @default.
• W2003148432 countsByYear W20031484322013 @default.
• W2003148432 countsByYear W20031484322014 @default.
• W2003148432 countsByYear W20031484322015 @default.
• W2003148432 countsByYear W20031484322016 @default.
• W2003148432 countsByYear W20031484322017 @default.
• W2003148432 countsByYear W20031484322018 @default.
• W2003148432 countsByYear W20031484322019 @default.
• W2003148432 countsByYear W20031484322020 @default.
• W2003148432 countsByYear W20031484322022 @default.
• W2003148432 countsByYear W20031484322023 @default.
• W2003148432 crossrefType "journal-article" @default.
• W2003148432 hasAuthorship W2003148432A5005536434 @default.
• W2003148432 hasAuthorship W2003148432A5006194428 @default.
• W2003148432 hasAuthorship W2003148432A5008766966 @default.
• W2003148432 hasAuthorship W2003148432A5017375737 @default.
• W2003148432 hasAuthorship W2003148432A5026915344 @default.
• W2003148432 hasAuthorship W2003148432A5030287146 @default.
• W2003148432 hasAuthorship W2003148432A5074653156 @default.
• W2003148432 hasAuthorship W2003148432A5089293072 @default.
• W2003148432 hasBestOaLocation W20031484321 @default.
• W2003148432 hasConcept C118303440 @default.
• W2003148432 hasConcept C126322002 @default.
• W2003148432 hasConcept C134018914 @default.
• W2003148432 hasConcept C16568411 @default.
• W2003148432 hasConcept C169760540 @default.
• W2003148432 hasConcept C170493617 @default.
• W2003148432 hasConcept C2776119998 @default.
• W2003148432 hasConcept C2777003273 @default.
• W2003148432 hasConcept C2779320081 @default.
• W2003148432 hasConcept C2779494582 @default.
• W2003148432 hasConcept C2779680196 @default.
• W2003148432 hasConcept C2780163352 @default.

• next