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• W2003149563 abstract "The effects of halide ions on severa pathways of lipid metabolism have been investigated in rat liver slices. Through the use of carboxyl-14C-labeled acetate and palmitate and U-14C-labeled glycine, striking differences were found when the effects of the four halide ions on the labeling of the lipids were compared Both fluoride and iodide depressed [14C]acetate incorporation into phosphatice and triglyceride fractions. The effects of the halide ions on the labeling of the phospho lipids and triglycerides from 14C-labeled palmitate differed greatly from the effects observed when [14C]acetate was the precursor of the lipid molecule. In contrast with the phospholipid fraction, the level of radioactivity from [14C]palmitate incorporated into the triglycerides was lower with fluoride than with chloride. The incorporation of [14C]glycine into the phospholipids was also greatly depressed by fluoride. The effects of halide ions on acetoacetate formation, on 14CO2 production and on the acetylcoenzyme A synthetase of rat liver were also investigated. Decreasing [1-14C]-acetate conversion to acetoacetate iodide had an opposite effect on 14CO2 production from the same labeled substrate. The effects of the four halide ions and the differences observed with the three labeled substrates on several pathways related to lipid metabolism are discussed." @default.
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• W2003149563 date "1975-02-01" @default.
• W2003149563 modified "2023-09-26" @default.
• W2003149563 title "Alterations in the metabolism of fats and phosphatides in rat liver induced by halide ions" @default.
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• W2003149563 doi "https://doi.org/10.1016/0009-2797(75)90103-9" @default.
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