FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003151421> ?p ?o ?g. }

• W2003151421 endingPage "869" @default.
• W2003151421 startingPage "869" @default.
• W2003151421 abstract "Hair represents an evolutionary innovation that appeared early on mammalian evolutionary history, and presumably contributed significantly to the rapid radiation of the group. An interesting event in hair evolution has been its secondary loss in some mammalian groups, such as cetaceans, whose hairless phenotype appears to be an adaptive response to better meet the environmental conditions. To determine whether different repertoire of keratin genes among mammals can potentially explain the phenotypic hair features of different lineages, we characterized the type I and II clusters of alpha keratins from eight mammalian species, including the hairless dolphin and minke whale representing the order Cetacea. We combined the available genomic information with phylogenetic analysis to conduct a comprehensive analysis of the evolutionary patterns of keratin gene clusters. We found that both type I and II gene clusters are fairly conserved among the terrestrial mammals included in this study, with lineage specific gene duplication and gene loss. Nevertheless, there is also evidence for an increased rate of pseudogenization in the cetacean lineage when compared to their terrestrial relatives, especially among the hair type keratins. Here we present a comprehensive characterization of alpha-keratin genes among mammals and elucidate the mechanisms involved in the evolution of this gene family. We identified lineage-specific gene duplications and gene loss among the Laurasiatherian and Euarchontoglires species included in the study. Interestingly, cetaceans present an increased loss of hair-type keratin genes when compared to other terrestrial mammals. As suggested by the ‘less-is-more’ hypothesis, we do not rule out the possibility that the gene loss of hair-type keratin genes in these species might be associated to the hairless phenotype and could have been adaptive in response to new selective pressures imposed by the colonization of a new habitat. Our study provides support for the idea that pseudogenes are not simply ‘genomic fossils’ but instead have adaptive roles during the evolutionary process." @default.
• W2003151421 created "2016-06-24" @default.
• W2003151421 creator A5053052855 @default.
• W2003151421 creator A5062397992 @default.
• W2003151421 creator A5080209573 @default.
• W2003151421 date "2014-01-01" @default.
• W2003151421 modified "2023-10-07" @default.
• W2003151421 title "Increased rate of hair keratin gene loss in the cetacean lineage" @default.
• W2003151421 cites W1633681515 @default.
• W2003151421 cites W1968261842 @default.
• W2003151421 cites W1972598615 @default.
• W2003151421 cites W1995119759 @default.
• W2003151421 cites W1999932584 @default.
• W2003151421 cites W2006500919 @default.
• W2003151421 cites W2018115687 @default.
• W2003151421 cites W2021804487 @default.
• W2003151421 cites W2023719581 @default.
• W2003151421 cites W2024157206 @default.
• W2003151421 cites W2033603067 @default.
• W2003151421 cites W2045395092 @default.
• W2003151421 cites W2066036014 @default.
• W2003151421 cites W2068310045 @default.
• W2003151421 cites W2072603644 @default.
• W2003151421 cites W2074512241 @default.
• W2003151421 cites W2094468743 @default.
• W2003151421 cites W2097554174 @default.
• W2003151421 cites W2098444377 @default.
• W2003151421 cites W2100473357 @default.
• W2003151421 cites W2128296317 @default.
• W2003151421 cites W2131593962 @default.
• W2003151421 cites W2132926880 @default.
• W2003151421 cites W2138222215 @default.
• W2003151421 cites W2146058063 @default.
• W2003151421 cites W2147295638 @default.
• W2003151421 cites W2152207030 @default.
• W2003151421 cites W2160576506 @default.
• W2003151421 cites W2167998778 @default.
• W2003151421 cites W2171193618 @default.
• W2003151421 cites W2171434741 @default.
• W2003151421 doi "https://doi.org/10.1186/1471-2164-15-869" @default.
• W2003151421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4195889" @default.
• W2003151421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25287022" @default.
• W2003151421 hasPublicationYear "2014" @default.
• W2003151421 type Work @default.
• W2003151421 sameAs 2003151421 @default.
• W2003151421 citedByCount "27" @default.
• W2003151421 countsByYear W20031514212015 @default.
• W2003151421 countsByYear W20031514212016 @default.
• W2003151421 countsByYear W20031514212017 @default.
• W2003151421 countsByYear W20031514212018 @default.
• W2003151421 countsByYear W20031514212019 @default.
• W2003151421 countsByYear W20031514212020 @default.
• W2003151421 countsByYear W20031514212021 @default.
• W2003151421 countsByYear W20031514212022 @default.
• W2003151421 countsByYear W20031514212023 @default.
• W2003151421 crossrefType "journal-article" @default.
• W2003151421 hasAuthorship W2003151421A5053052855 @default.
• W2003151421 hasAuthorship W2003151421A5062397992 @default.
• W2003151421 hasAuthorship W2003151421A5080209573 @default.
• W2003151421 hasBestOaLocation W20031514211 @default.
• W2003151421 hasConcept C104317684 @default.
• W2003151421 hasConcept C127716648 @default.
• W2003151421 hasConcept C150194340 @default.
• W2003151421 hasConcept C2776817793 @default.
• W2003151421 hasConcept C54355233 @default.
• W2003151421 hasConcept C5911399 @default.
• W2003151421 hasConcept C7602840 @default.
• W2003151421 hasConcept C78458016 @default.
• W2003151421 hasConcept C81241287 @default.
• W2003151421 hasConcept C86803240 @default.
• W2003151421 hasConcept C90132467 @default.
• W2003151421 hasConceptScore W2003151421C104317684 @default.
• W2003151421 hasConceptScore W2003151421C127716648 @default.
• W2003151421 hasConceptScore W2003151421C150194340 @default.
• W2003151421 hasConceptScore W2003151421C2776817793 @default.
• W2003151421 hasConceptScore W2003151421C54355233 @default.
• W2003151421 hasConceptScore W2003151421C5911399 @default.
• W2003151421 hasConceptScore W2003151421C7602840 @default.
• W2003151421 hasConceptScore W2003151421C78458016 @default.
• W2003151421 hasConceptScore W2003151421C81241287 @default.
• W2003151421 hasConceptScore W2003151421C86803240 @default.
• W2003151421 hasConceptScore W2003151421C90132467 @default.
• W2003151421 hasIssue "1" @default.
• W2003151421 hasLocation W20031514211 @default.
• W2003151421 hasLocation W20031514212 @default.
• W2003151421 hasLocation W20031514213 @default.
• W2003151421 hasLocation W20031514214 @default.
• W2003151421 hasOpenAccess W2003151421 @default.
• W2003151421 hasPrimaryLocation W20031514211 @default.
• W2003151421 hasRelatedWork W1984675152 @default.
• W2003151421 hasRelatedWork W2041624900 @default.
• W2003151421 hasRelatedWork W2053757086 @default.
• W2003151421 hasRelatedWork W2069688179 @default.
• W2003151421 hasRelatedWork W2098444377 @default.
• W2003151421 hasRelatedWork W2261858970 @default.
• W2003151421 hasRelatedWork W2552280213 @default.
• W2003151421 hasRelatedWork W3129501535 @default.
• W2003151421 hasRelatedWork W4229549692 @default.

• next