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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003151572> ?p ?o ?g. }

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• W2003151572 abstract "Liver X receptors (LXRs) are nuclear receptors that act as metabolic sensors for cellular cholesterol (Xol) and oxysterol content. Increased oxysterol levels activate LXRs, which then induce: the removal of cholesterol out of peripheral cells; transport of this cholesterol to the liver; excretion of cholesterol through production of bile acids; and inhibition of intestinal cholesterol absorption. Recent evidence indicates that LXRs are not only master regulators of cholesterol homeostasis, but also decrease the development of atherosclerosis – a disease intimately linked with abnormal cholesterol homeostasis. This evidence shows that LXRs are promising drug development targets for atherosclerosis." @default.
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• W2003151572 date "2002-10-01" @default.
• W2003151572 modified "2023-09-26" @default.
• W2003151572 title "Liver X receptors: Xcreting Xol to combat atherosclerosis" @default.
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• W2003151572 doi "https://doi.org/10.1016/s1471-4914(02)02400-0" @default.
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