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- W2003152894 abstract "Mutants resistant to ML236B (compactin) were isolated from the Chinese hamster lung V79 cell line (1). Three ML236B-resistant mutants, MF-1, MF-2 and MF-3, were enhanced in insulin-specific binding activity about 2 to 3 times over the parental V79 cell lines. Compared to V79, endocytosis of insulin was also increased 2 to 3-fold in ML236B-resistant mutants than V79. Scatchard analysis showed that 5,000 insulin binding sites per cell in V79 and 16,000 in a NL236B-resistant clone, MF-2. Insulin receptors in mutant and parental strains are down-regulated to a similar extent in the parental V79 treated with an excess insulin. This is the first somatic cell mutant with increased surface binding sites for insulin." @default.
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- W2003152894 date "1983-11-01" @default.
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- W2003152894 title "Increased surface binding sites of insulin in ML236B (compactin)-resistant mutants of Chinese hamster cell line" @default.
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- W2003152894 doi "https://doi.org/10.1016/0006-291x(83)91534-6" @default.
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