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• W2003153311 abstract "Stochastic gene expression can lead to phenotypic differences among cells even in isogenic populations growing under macroscopically identical conditions. Here, we apply flux balance analysis in investigating the effects of single-cell proteomics data on the metabolic behavior of an in silico Escherichia coli population. We use the latest metabolic reconstruction integrated with transcriptional regulatory data to model realistic cells growing in a glucose minimal medium under aerobic conditions. The modeled population exhibits a broad distribution of growth rates, and principal component analysis was used to identify well-defined subpopulations that differ in terms of their pathway use. The cells differentiate into slow-growing acetate-secreting cells and fast-growing CO 2 -secreting cells, and a large population growing at intermediate rates shift from glycolysis to Entner–Doudoroff pathway use. Constraints imposed by integrating regulatory data have a large impact on NADH oxidizing pathway use within the cell. Finally, we find that stochasticity in the expression of only a few genes may be sufficient to capture most of the metabolic variability of the entire population." @default.
• W2003153311 created "2016-06-24" @default.
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• W2003153311 date "2013-08-01" @default.
• W2003153311 modified "2023-10-11" @default.
• W2003153311 title "Heterogeneity in protein expression induces metabolic variability in a modeled <i>Escherichia coli</i> population" @default.
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• W2003153311 doi "https://doi.org/10.1073/pnas.1222569110" @default.
• W2003153311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3752265" @default.
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