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- W2003155613 abstract "To assess and compare the compliance with anti-HBV antiviral oral drugs A pharmaco-epidemiological study, based on the IMS LifeLinkTM Treatment Dynamics (LTD) database was used to investigate the frequency and the regularity of patients’ deliveries on retail pharmacies for 18 months follow-up period between June 2012 and November 2013. Incident patients with no anti-HBV drug deliveries within the last 3 months were included in the cohort. For the follow-up period, patients with no anti-HBV deliveries in a retail pharmacy within 3 consecutive months were considered having stopped their treatment which can lead to an overestimation due to the double dispensing system of these drugs in France. Study investigated patients’ demographic characteristics, persistence rates, medication possession ratio (MPR) and proportion of days covered (PDC) according to initial molecule. 793 patients (median age 50 years old) initiated a treatment against HBV (patient with both anti-HBV and HIV treatments were excluded); for the follow-up period, 5% of patients switched HBV treatment; 32% of patients stopped their treatment for the follow-up period. Patients who continued their treatment are compliant as MPR is respectively of 160% and 103% at 6 and 12 months while PDC values are 82% and 78%. No differences stood out among the different treatments, especially between Tenofovir and Entecavir (the two often prescribed HBV drugs). Moreover older patients tend to be more compliant than the youngest one. By using the IMS Lifelink longitudinal database this study highlights the fact that one third of patients treated with anti-HBV treatment stopped it within 18 months while these drugs are well tolerated. Therefore physicians’ challenge consists consequently in motivating patients to continue their treatment even they feel asymptomatic." @default.
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- W2003155613 date "2014-11-01" @default.
- W2003155613 modified "2023-09-26" @default.
- W2003155613 title "Persistence to Treatment of Chronic Hepatitis B Virus (Hbv) Infection: A Study Based on the French Ims Lifelink Treatment Dynamics (LTD) Database" @default.
- W2003155613 doi "https://doi.org/10.1016/j.jval.2014.08.2539" @default.
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