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- W2003156265 abstract "Cell surface receptors mediate many cellular responses in health and disease. Recent progress in our understanding of how ligand binding to the extracellular domains of receptors triggers intracellular signaling has underlined the role of ligand-promoted receptor clustering following by oligomerization of the cytoplasmic signaling domains. The clustering suggests the requirement of ligand multivalency and is especially important for triggering receptors involved in innate and adaptive immune responses. However, although numerous studies have established that multivalent, but not monovalent, ligands induce receptor-mediated signal transduction, considerable uncertainty still remains. Here, I hypothesize that “monovalent” ligands that have been reported to trigger immune receptors in vitro are not necessarily truly monovalent. This is illustrated by focusing on studies of signal transduction by toll-like receptor-4 and T cell receptor. By generalizing this concept to a variety of lipid and protein ligands, one would propose an alternative interpretation of apparent ligand monovalency in other receptor activation studies as well." @default.
- W2003156265 created "2016-06-24" @default.
- W2003156265 creator A5016467167 @default.
- W2003156265 date "2012-07-01" @default.
- W2003156265 modified "2023-09-27" @default.
- W2003156265 title "“Monovalent” ligands that trigger TLR-4 and TCR are not necessarily truly monovalent" @default.
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- W2003156265 doi "https://doi.org/10.1016/j.molimm.2012.03.031" @default.
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