FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003160879> ?p ?o ?g. }

• W2003160879 endingPage "963" @default.
• W2003160879 startingPage "955" @default.
• W2003160879 abstract "Chemoprevention may be one way to prevent lung cancer in smokers who are motivated to quit but cannot stop. The approach to chemoprevention of lung cancer described in this article is based on an understanding of the lung carcinogens present in tobacco smoke. The available data indicate that the compounds in cigarette smoke most likely involved in the induction of lung cancer in humans are the complex of polynuclear aromatic hydrocarbons typified by benzo[a]pyrene (B[a]P) and the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). A large number of compounds are now available that inhibit lung tumorigenesis by B[a]P or NNK in rodents. Inhibition of NNK-induced lung carcinogenesis by phenethyl isothiocyanate (PEITC) and inhibition of B[a]P-induced lung carcinogenesis by benzyl isothiocyanate (BITC) are discussed as examples. Studies with PEITC in rodents clearly demonstrate that it inhibits NNK-induced lung tumorigenesis by inhibiting the metabolic activation of NNK. Similar changes appear to occur in humans according to data generated in smokers who ate watercress, a source of PEITC. It is likely that mixtures of chemopreventive agents with activity against carcinogens in tobacco smoke, such as NNK and B[a]P, will be useful in chemoprevention of lung cancer in smokers. Furthermore, there is a need to develop suppressing agents for lung cancer that might be applicable in both smokers and ex-smokers." @default.
• W2003160879 created "2016-06-24" @default.
• W2003160879 creator A5033402104 @default.
• W2003160879 date "1997-06-01" @default.
• W2003160879 modified "2023-09-27" @default.
• W2003160879 title "Approaches to chemoprevention of lung cancer based on carcinogens in tobacco smoke." @default.
• W2003160879 cites W1489513538 @default.
• W2003160879 cites W1503109103 @default.
• W2003160879 cites W1526215225 @default.
• W2003160879 cites W1551396483 @default.
• W2003160879 cites W1552426876 @default.
• W2003160879 cites W1596485672 @default.
• W2003160879 cites W1637996374 @default.
• W2003160879 cites W1642374095 @default.
• W2003160879 cites W1816447251 @default.
• W2003160879 cites W1831851200 @default.
• W2003160879 cites W1833006660 @default.
• W2003160879 cites W1858424027 @default.
• W2003160879 cites W1897120345 @default.
• W2003160879 cites W1897738545 @default.
• W2003160879 cites W1901337917 @default.
• W2003160879 cites W1930455798 @default.
• W2003160879 cites W1959216631 @default.
• W2003160879 cites W1963182291 @default.
• W2003160879 cites W1966368391 @default.
• W2003160879 cites W1968567048 @default.
• W2003160879 cites W1975066159 @default.
• W2003160879 cites W1976128207 @default.
• W2003160879 cites W1977943541 @default.
• W2003160879 cites W1979892584 @default.
• W2003160879 cites W1982153589 @default.
• W2003160879 cites W1982223979 @default.
• W2003160879 cites W1986494927 @default.
• W2003160879 cites W1993040746 @default.
• W2003160879 cites W2001710189 @default.
• W2003160879 cites W2002202982 @default.
• W2003160879 cites W2010702550 @default.
• W2003160879 cites W2010974779 @default.
• W2003160879 cites W2016155710 @default.
• W2003160879 cites W2016500076 @default.
• W2003160879 cites W2017459276 @default.
• W2003160879 cites W2020641997 @default.
• W2003160879 cites W2024289938 @default.
• W2003160879 cites W2027377609 @default.
• W2003160879 cites W2027625544 @default.
• W2003160879 cites W2028183427 @default.
• W2003160879 cites W2032878733 @default.
• W2003160879 cites W2033513162 @default.
• W2003160879 cites W2035143616 @default.
• W2003160879 cites W2040332720 @default.
• W2003160879 cites W2044220239 @default.
• W2003160879 cites W2044936196 @default.
• W2003160879 cites W2044943027 @default.
• W2003160879 cites W2048649566 @default.
• W2003160879 cites W2052034749 @default.
• W2003160879 cites W2061805255 @default.
• W2003160879 cites W2065171941 @default.
• W2003160879 cites W2066583195 @default.
• W2003160879 cites W2069919465 @default.
• W2003160879 cites W2070406260 @default.
• W2003160879 cites W2072631673 @default.
• W2003160879 cites W2084394063 @default.
• W2003160879 cites W2085039235 @default.
• W2003160879 cites W2088343256 @default.
• W2003160879 cites W2090573318 @default.
• W2003160879 cites W2093277278 @default.
• W2003160879 cites W2096331007 @default.
• W2003160879 cites W2097469649 @default.
• W2003160879 cites W2099931746 @default.
• W2003160879 cites W2103376120 @default.
• W2003160879 cites W2105689804 @default.
• W2003160879 cites W2125831750 @default.
• W2003160879 cites W2126048287 @default.
• W2003160879 cites W2131107777 @default.
• W2003160879 cites W2148422042 @default.
• W2003160879 cites W2149962457 @default.
• W2003160879 cites W2154440819 @default.
• W2003160879 cites W2162443197 @default.
• W2003160879 cites W2162500283 @default.
• W2003160879 cites W2163237503 @default.
• W2003160879 cites W2165857243 @default.
• W2003160879 cites W2169688916 @default.
• W2003160879 cites W2173028042 @default.
• W2003160879 cites W2270018755 @default.
• W2003160879 doi "https://doi.org/10.1289/ehp.97105s4955" @default.
• W2003160879 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1470048" @default.
• W2003160879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9255587" @default.
• W2003160879 hasPublicationYear "1997" @default.
• W2003160879 type Work @default.
• W2003160879 sameAs 2003160879 @default.
• W2003160879 citedByCount "43" @default.
• W2003160879 countsByYear W20031608792013 @default.
• W2003160879 countsByYear W20031608792014 @default.
• W2003160879 countsByYear W20031608792015 @default.
• W2003160879 countsByYear W20031608792017 @default.
• W2003160879 countsByYear W20031608792018 @default.
• W2003160879 countsByYear W20031608792020 @default.
• W2003160879 countsByYear W20031608792021 @default.

• next