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• W2003161103 abstract "Kari Stefansson and colleagues report association of a variant in LINGO1 with risk of essential tremor, a common progressive neurological disease. Mice lacking Lingo1 have impaired axonal integrity, which may be relevant to the pathophysiology of the human disease. We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 × 10−9, odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse knockout models highlights the potential role of LINGO1 in the pathophysiology of essential tremor." @default.
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• W2003161103 date "2009-02-01" @default.
• W2003161103 modified "2023-10-10" @default.
• W2003161103 title "Variant in the sequence of the LINGO1 gene confers risk of essential tremor" @default.
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• W2003161103 doi "https://doi.org/10.1038/ng.299" @default.
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