FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003161682> ?p ?o ?g. }

• W2003161682 endingPage "159" @default.
• W2003161682 startingPage "147" @default.
• W2003161682 abstract "The neuropeptide CRH is the central regulator of the hypothalamic-pituitary-adrenal (HPA) stress response system and is implicated in various stress-related conditions. In the neurodegenerative disorder Alzheimer's disease (AD), levels of CRH are decreased. AD pathology is characterized by the deposition of the nonsoluble amyloid beta protein (A beta), oxidative stress, and neuronal cell death. Employing primary neurons and clonal cells, we demonstrate that CRH has a neuroprotective activity in CRH-receptor type 1 (CRH-R1)-expressing neurons against oxidative cell death. The protective effect of CRH was blocked by selective and nonselective CRH-R1 antagonists and by protein kinase A inhibitors. Overexpression of CRH-R1 in clonal hippocampal cells lacking endogenous CRH-receptors established neuroprotection by CRH. The activation of CRH-R1 and neuroprotection are accompanied by an increased release of non-amyloidogenic soluble A beta precursor protein. At the molecular level CRH caused the suppression of the DNA-binding activity and transcriptional activity of the transcription factor NF-kappaB. Suppression of NF-kappaB by overexpression of a super-repressor mutant form of IkappaB-alpha, a specific inhibitor of NF-kappaB, led to protection of the cells against oxidative stress. These data demonstrate a novel cytoprotective effect of CRH that is mediated by CRH-R1 and downstream by suppression of NF-kappaB and indicate CRH as an endogenous protective neuropeptide against oxidative cell death in addition to its function in the HPA-system. Moreover, the protective function of CRH proposes a molecular link between oxidative stress-related degenerative events and the CRH-R1 system." @default.
• W2003161682 created "2016-06-24" @default.
• W2003161682 creator A5004758910 @default.
• W2003161682 creator A5005980892 @default.
• W2003161682 creator A5019893954 @default.
• W2003161682 creator A5088203588 @default.
• W2003161682 date "2000-01-01" @default.
• W2003161682 modified "2023-09-27" @default.
• W2003161682 title "Corticotropin-Releasing Hormone-Mediated Neuroprotection against Oxidative Stress Is Associated with the Increased Release of Non-amyloidogenic Amyloid β Precursor Protein and with the Suppression of Nuclear Factor-κB" @default.
• W2003161682 cites W1482682744 @default.
• W2003161682 cites W1492606093 @default.
• W2003161682 cites W1497061219 @default.
• W2003161682 cites W1568529372 @default.
• W2003161682 cites W1599831143 @default.
• W2003161682 cites W1605460006 @default.
• W2003161682 cites W1888783223 @default.
• W2003161682 cites W1915074145 @default.
• W2003161682 cites W1968786165 @default.
• W2003161682 cites W1970706135 @default.
• W2003161682 cites W1975627206 @default.
• W2003161682 cites W1977382795 @default.
• W2003161682 cites W1983987381 @default.
• W2003161682 cites W1990543766 @default.
• W2003161682 cites W1991743392 @default.
• W2003161682 cites W1994320218 @default.
• W2003161682 cites W1994662389 @default.
• W2003161682 cites W2007133768 @default.
• W2003161682 cites W2010715645 @default.
• W2003161682 cites W2012566346 @default.
• W2003161682 cites W2014457539 @default.
• W2003161682 cites W2016293448 @default.
• W2003161682 cites W2016730049 @default.
• W2003161682 cites W2017688783 @default.
• W2003161682 cites W2021620960 @default.
• W2003161682 cites W2027580766 @default.
• W2003161682 cites W2029205666 @default.
• W2003161682 cites W2036904165 @default.
• W2003161682 cites W2038516967 @default.
• W2003161682 cites W2039706098 @default.
• W2003161682 cites W2046847750 @default.
• W2003161682 cites W2059457068 @default.
• W2003161682 cites W2063081233 @default.
• W2003161682 cites W2065257477 @default.
• W2003161682 cites W2068818952 @default.
• W2003161682 cites W2069159032 @default.
• W2003161682 cites W2071070948 @default.
• W2003161682 cites W2072801092 @default.
• W2003161682 cites W2073057727 @default.
• W2003161682 cites W2081554944 @default.
• W2003161682 cites W2081678091 @default.
• W2003161682 cites W2082146795 @default.
• W2003161682 cites W2082575834 @default.
• W2003161682 cites W2082876506 @default.
• W2003161682 cites W2084015178 @default.
• W2003161682 cites W2090737341 @default.
• W2003161682 cites W2091094196 @default.
• W2003161682 cites W2095036452 @default.
• W2003161682 cites W2111398489 @default.
• W2003161682 cites W2127061690 @default.
• W2003161682 cites W2134673151 @default.
• W2003161682 cites W2137775389 @default.
• W2003161682 cites W2151892297 @default.
• W2003161682 cites W2157786523 @default.
• W2003161682 cites W2158748165 @default.
• W2003161682 cites W2166781237 @default.
• W2003161682 cites W4376848280 @default.
• W2003161682 doi "https://doi.org/10.1210/mend.14.1.0403" @default.
• W2003161682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10628754" @default.
• W2003161682 hasPublicationYear "2000" @default.
• W2003161682 type Work @default.
• W2003161682 sameAs 2003161682 @default.
• W2003161682 citedByCount "60" @default.
• W2003161682 countsByYear W20031616822013 @default.
• W2003161682 countsByYear W20031616822015 @default.
• W2003161682 countsByYear W20031616822017 @default.
• W2003161682 countsByYear W20031616822018 @default.
• W2003161682 countsByYear W20031616822019 @default.
• W2003161682 countsByYear W20031616822020 @default.
• W2003161682 countsByYear W20031616822022 @default.
• W2003161682 crossrefType "journal-article" @default.
• W2003161682 hasAuthorship W2003161682A5004758910 @default.
• W2003161682 hasAuthorship W2003161682A5005980892 @default.
• W2003161682 hasAuthorship W2003161682A5019893954 @default.
• W2003161682 hasAuthorship W2003161682A5088203588 @default.
• W2003161682 hasBestOaLocation W20031616821 @default.
• W2003161682 hasConcept C126322002 @default.
• W2003161682 hasConcept C134018914 @default.
• W2003161682 hasConcept C169760540 @default.
• W2003161682 hasConcept C190283241 @default.
• W2003161682 hasConcept C25498285 @default.
• W2003161682 hasConcept C2776151105 @default.
• W2003161682 hasConcept C2778458438 @default.
• W2003161682 hasConcept C31573885 @default.
• W2003161682 hasConcept C55493867 @default.
• W2003161682 hasConcept C71315377 @default.
• W2003161682 hasConcept C71924100 @default.
• W2003161682 hasConcept C86803240 @default.
• W2003161682 hasConcept C95444343 @default.

• next