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• W2003162724 abstract "The purpose of the study was to examine glucose kinetics and substrate utilization during isocaloric exercise at different intensities in NIDDM patients. Six male NIDDM patients (N) and 6 male controls (C) of similar age, body weight,% body fat, and VO2peak participated in the study. Each subject underwent two exercise sessions administered in a counterbalanced order. During each exercise session, the subjects cycled at a power output corresponding to 50% VO2peak for 70 min (LO) or 70% VO2peak for 50 min (HI). Isotope infusion technique and indirect calorimetry were used to evaluate glucose turnover and substrate utilization during exercise. At rest, fasting plasma concentrations of glucose (GLU), free fatty acid (FFA) and insulin (INS) were higher (p<0.05) in N than C (11.5±1.2 vs. 5.4±0.2 mM, 0.61±0.08 vs. 0.49±0.05 mM, 14.42±3.57 vs. 8.32±1.95 μU·ml-1, respectively). The rate of glucose appearance (Ra) was greater (p<0.05) in N than C(14.5±1.6 vs. 10.9±0.7μmol·min-1·kg-1). The rate of glucose disappearance (Rd) did not differ between N and C. During LO, GLU decreased (p<0.05) by 17% in N and 11% in C. Ra increased(p<0.05) by 38% in N and 75% in C. Rd increased (p<0.05) by 77% in N and 85% in C. During HI, GLU decreased (p<0.05) by 19% in N and 10% in C. Ra increased (p<0.05) by 40% in N and 90% in C. Rd increased (p<0.05) by 80% in N and 109% in C. During both LO and HI, FFA remained unchanged in N but increased (p<0.05) in C. INS remained unchanged in N but decreased (p<0.05) in C. The cumulative carbohydrate oxidation, plasma glucose utilization, and muscle glycogen utilization during LO or HI were similar between N and C. It is concluded that in NIDDM patients 1) exercise at 70% VO2peak for 50 min and exercise at 50% VO2peak for 70 min result in a similar decrease in plasma glucose level; 2) the exercise-induced decrease in plasma glucose level is attributable to a more pronounced increase in peripheral glucose uptake; 3) the mechanisms which govern substrate utilization during exercise compensate for hyperglycemia and insulin resistance." @default.
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• W2003162724 date "1996-05-01" @default.
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• W2003162724 title "GLUCOSE KINETICS AND SUBSTRATE UTILIZATION DURING ISOCALORIC EXERCISE AT DIFFERENT INTENSITIES IN NIDDM PATIENTS 616" @default.
• W2003162724 doi "https://doi.org/10.1097/00005768-199605001-00615" @default.
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