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• W2003163110 abstract "The cyclopentenone prostaglandin 15-deoxy-Δ^12,14-prostaglandin J₂ (15d-PGJ₂) is recognized as a potent lipid mediator that is derived from PGD₂, which is produced abundantly in allergic inflammatory sites. It is now established that 15d-PGJ₂ negatively regulates cellular functions through its intracellular targets such as peroxisome proliferator-activated receptor-γ (PPARγ). However, recent studies revealed that 15d-PGJ₂ appears to possess not only anti-inflammatory activities but also a proinflammatory potential depending on its concentration and the activation state of the target cell. For instance, at low concentrations, 15d-PGJ₂ enhances eotaxin-induced chemotaxis, shape change, and actin reorganization in eosinophils through its ligation with PPARγ. Moreover, 15d-PGJ₂ itself is a potent chemoattractant, and it induces calcium mobilization, and up-regulates CD11b expression through its membrane receptor – chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). Conversely, at high concentrations, 15d-PGJ₂ inhibits eosinophil survival by inducing apoptosis in a PPARγ-independent manner. Here, we discuss the pathophysiological roles of 15d-PGJ₂ that could act as a paracrine, autocrine, and intracrine substance to regulate eosinophil functions." @default.
• W2003163110 created "2016-06-24" @default.
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• W2003163110 date "2007-01-01" @default.
• W2003163110 modified "2023-09-27" @default.
• W2003163110 title "Anti- and Proinflammatory Effects of 15-Deoxy-Δ^12,14-Prostaglandin J₂(15d-PGJ₂) on Human Eosinophil Functions" @default.
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• W2003163110 doi "https://doi.org/10.1159/000101399" @default.
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