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- W2003164196 abstract "Rats that are fed for 90 min per day can stabilize their weight after an initial drop; however, if rats on this feeding schedule are also given access to a running wheel, they run excessively, eat less, lose weight, and often die. To investigate this phenomenon as a possible animal model of obsessive-compulsive disorder (OCD), rats were treated for 5 weeks with fluoxetine, an antidepressant that relieves OCD symptoms in humans (5 mg/kg, 2.5 mg/kg), or imipramine, an antidepressant that does not affect OCD symptoms (5 mg/kg), or saline prior to exposure to food restriction and the running wheel. In addition, because chronic fluoxetine treatment is thought to enhance serotonergic neurotransmission, for contrast an additional group of rats were treated with parachlorophenylalanine (PCPA), a tryptophan hydroxylase inhibitor that depletes serotonin. Rats treated with fluoxetine lost significantly less weight, ran significantly less, and increased food intake more rapidly during restriction of food availability than saline-treated rats. Rats treated with imipramine did not differ from those treated with saline on these parameters. Compared to saline-treated rats, rats treated with PCPA lost more weight, ate less food, and increased running more rapidly. These effects of pharmacological treatment indicate an inverse relationhip between central serotonergic activity and vulnerability to develop food-restriction-induced anorexia and compulsive running. In addition, like OCD in humans, this phenomenon in rats seems to be blocked by chronic treatment with a serotonin selective reuptake inhibitor but not a less selective monoamine reuptake inhibitor." @default.
- W2003164196 created "2016-06-24" @default.
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- W2003164196 date "1996-01-01" @default.
- W2003164196 modified "2023-09-23" @default.
- W2003164196 title "Effects of serotonergic agents on food-restriction-induced hyperactivity" @default.
- W2003164196 cites W149585525 @default.
- W2003164196 cites W1510792100 @default.
- W2003164196 cites W1579276202 @default.
- W2003164196 cites W1602485996 @default.
- W2003164196 cites W1661406670 @default.
- W2003164196 cites W1787296647 @default.
- W2003164196 cites W1878649398 @default.
- W2003164196 cites W1897977266 @default.
- W2003164196 cites W195626614 @default.
- W2003164196 cites W1966242764 @default.
- W2003164196 cites W1971390079 @default.
- W2003164196 cites W1972347938 @default.
- W2003164196 cites W1975697963 @default.
- W2003164196 cites W1976208970 @default.
- W2003164196 cites W1988060646 @default.
- W2003164196 cites W1991741399 @default.
- W2003164196 cites W1994222437 @default.
- W2003164196 cites W1997841936 @default.
- W2003164196 cites W2001271084 @default.
- W2003164196 cites W2001841394 @default.
- W2003164196 cites W2001850627 @default.
- W2003164196 cites W2001893860 @default.
- W2003164196 cites W2007270442 @default.
- W2003164196 cites W2008311204 @default.
- W2003164196 cites W2009724876 @default.
- W2003164196 cites W2012879187 @default.
- W2003164196 cites W2014463305 @default.
- W2003164196 cites W2014956678 @default.
- W2003164196 cites W2016955904 @default.
- W2003164196 cites W2017838119 @default.
- W2003164196 cites W2022106712 @default.
- W2003164196 cites W2025444171 @default.
- W2003164196 cites W2029534735 @default.
- W2003164196 cites W2034324440 @default.
- W2003164196 cites W2038191735 @default.
- W2003164196 cites W2042784380 @default.
- W2003164196 cites W2045874891 @default.
- W2003164196 cites W2046973112 @default.
- W2003164196 cites W2047455747 @default.
- W2003164196 cites W2050252906 @default.
- W2003164196 cites W2050335342 @default.
- W2003164196 cites W2051872016 @default.
- W2003164196 cites W2054273915 @default.
- W2003164196 cites W205687278 @default.
- W2003164196 cites W2060523091 @default.
- W2003164196 cites W2060626931 @default.
- W2003164196 cites W2061831951 @default.
- W2003164196 cites W2064777923 @default.
- W2003164196 cites W2066346448 @default.
- W2003164196 cites W2066899220 @default.
- W2003164196 cites W2078534896 @default.
- W2003164196 cites W2079668415 @default.
- W2003164196 cites W2080631821 @default.
- W2003164196 cites W2081033561 @default.
- W2003164196 cites W2081459038 @default.
- W2003164196 cites W2085068332 @default.
- W2003164196 cites W2088440837 @default.
- W2003164196 cites W2089868635 @default.
- W2003164196 cites W2090451320 @default.
- W2003164196 cites W2091291914 @default.
- W2003164196 cites W2093980361 @default.
- W2003164196 cites W2094997664 @default.
- W2003164196 cites W210048544 @default.
- W2003164196 cites W2100572873 @default.
- W2003164196 cites W2106562863 @default.
- W2003164196 cites W2107147149 @default.
- W2003164196 cites W2119435176 @default.
- W2003164196 cites W2124720308 @default.
- W2003164196 cites W2135409689 @default.
- W2003164196 cites W2141634534 @default.
- W2003164196 cites W2156833765 @default.
- W2003164196 cites W2159011576 @default.
- W2003164196 cites W2163215067 @default.
- W2003164196 cites W2169460958 @default.
- W2003164196 cites W2172295790 @default.
- W2003164196 cites W2242860543 @default.
- W2003164196 cites W2461646296 @default.
- W2003164196 cites W2491523732 @default.
- W2003164196 cites W2888477666 @default.
- W2003164196 cites W2938326 @default.
- W2003164196 cites W614320008 @default.
- W2003164196 cites W618093999 @default.
- W2003164196 cites W840308884 @default.
- W2003164196 cites W2067335800 @default.
- W2003164196 doi "https://doi.org/10.1016/0091-3057(95)02003-9" @default.
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