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- W2003165067 abstract "In Brief Study Design. Double-blind, placebo-controlled randomized clinical trial. Objective. To assess the efficacy of 1 preoperative 1.5 g dose of cefuroxime in preventing surgical site infection after surgery for herniated disc. Summary of Background Data. Antibiotic prophylaxis was only tested in nonconclusive trials in this setting. Methods. The study was conducted in 2 university hospitals in Switzerland. Patients were assessed for occurrence of surgical site infection (defined by the criteria of the Centers for Diseases Control and Prevention), other infections, or adverse events up to 6 months after surgery. Outcome measures were compared in a univariate, per-protocol analysis. Results. Baseline characteristics were similar in patients allocated to cefuroxime (n = 613) or placebo (n = 624). Eight (1.3%) patients in the cefuroxime group and 18 patients (2.8%) in the placebo group developed a surgical site infection (P = 0.073). A diagnosis of spondylodiscitis or epidural abscess was made in 9 patients in the placebo group, but none in the cefuroxime group (P < 0.01), which corresponded to a number necessary to treat of 69 patients to prevent one of these infections. There were no significant adverse events attributed to either cefuroxime or placebo. Conclusion. A single, preoperative dose of cefuroxime significantly reduces the risk of organ-space infection, most notably spondylodiscitis, after surgery for herniated disc. The impact of antibiotic prophylaxis was never proven in herniated disc surgery. In a double-blind trial, 1 preoperative 1.5 g dose of cefuroxime significantly prevented organ-space infections in this setting: spondylodiscitis or epidural abscess occurred in 0/613 patients who received cefuroxime, compared with 9/624 patients who received placebo." @default.
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- W2003165067 date "2008-08-01" @default.
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- W2003165067 title "Cefuroxime Prophylaxis Is Effective in Noninstrumented Spine Surgery" @default.
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- W2003165067 doi "https://doi.org/10.1097/brs.0b013e31817d97cf" @default.
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