Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003165077> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2003165077 endingPage "393" @default.
- W2003165077 startingPage "390" @default.
- W2003165077 abstract "Ensuring the availability of new antibiotics to eradicate resistant pathogens is a critical issue, but very few new antibacterials have been recently commercialized. In an effort to rationalize their discovery process, the industry has utilized chemical library and high-throughput approaches already applied in other therapeutical areas to generate new antibiotics. This strategy has turned out to be poorly adapted to the reality of antibacterial discovery. Commercial chemical libraries contain molecules with specific molecular properties, and unfortunately systemic antibacterials are more hydrophilic and have more complex structures. These factors are critical, since hydrophobic antibiotics are generally inactive in the presence of serum. Here, we review how the skewed distribution of systemic antibiotics in chemical space influences the discovery process." @default.
- W2003165077 created "2016-06-24" @default.
- W2003165077 creator A5000771904 @default.
- W2003165077 creator A5042256682 @default.
- W2003165077 creator A5042699767 @default.
- W2003165077 creator A5056684035 @default.
- W2003165077 creator A5085438218 @default.
- W2003165077 date "2009-01-01" @default.
- W2003165077 modified "2023-09-27" @default.
- W2003165077 title "The Antibiotics in the Chemical Space" @default.
- W2003165077 doi "https://doi.org/10.2174/092986709787002628" @default.
- W2003165077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19149585" @default.
- W2003165077 hasPublicationYear "2009" @default.
- W2003165077 type Work @default.
- W2003165077 sameAs 2003165077 @default.
- W2003165077 citedByCount "18" @default.
- W2003165077 countsByYear W20031650772013 @default.
- W2003165077 countsByYear W20031650772014 @default.
- W2003165077 countsByYear W20031650772015 @default.
- W2003165077 countsByYear W20031650772017 @default.
- W2003165077 countsByYear W20031650772021 @default.
- W2003165077 countsByYear W20031650772022 @default.
- W2003165077 countsByYear W20031650772023 @default.
- W2003165077 crossrefType "journal-article" @default.
- W2003165077 hasAuthorship W2003165077A5000771904 @default.
- W2003165077 hasAuthorship W2003165077A5042256682 @default.
- W2003165077 hasAuthorship W2003165077A5042699767 @default.
- W2003165077 hasAuthorship W2003165077A5056684035 @default.
- W2003165077 hasAuthorship W2003165077A5085438218 @default.
- W2003165077 hasConcept C111919701 @default.
- W2003165077 hasConcept C127413603 @default.
- W2003165077 hasConcept C171250308 @default.
- W2003165077 hasConcept C183696295 @default.
- W2003165077 hasConcept C185592680 @default.
- W2003165077 hasConcept C192562407 @default.
- W2003165077 hasConcept C41008148 @default.
- W2003165077 hasConcept C501593827 @default.
- W2003165077 hasConcept C55493867 @default.
- W2003165077 hasConcept C70721500 @default.
- W2003165077 hasConcept C74187038 @default.
- W2003165077 hasConcept C86803240 @default.
- W2003165077 hasConcept C89423630 @default.
- W2003165077 hasConcept C98045186 @default.
- W2003165077 hasConcept C99726746 @default.
- W2003165077 hasConceptScore W2003165077C111919701 @default.
- W2003165077 hasConceptScore W2003165077C127413603 @default.
- W2003165077 hasConceptScore W2003165077C171250308 @default.
- W2003165077 hasConceptScore W2003165077C183696295 @default.
- W2003165077 hasConceptScore W2003165077C185592680 @default.
- W2003165077 hasConceptScore W2003165077C192562407 @default.
- W2003165077 hasConceptScore W2003165077C41008148 @default.
- W2003165077 hasConceptScore W2003165077C501593827 @default.
- W2003165077 hasConceptScore W2003165077C55493867 @default.
- W2003165077 hasConceptScore W2003165077C70721500 @default.
- W2003165077 hasConceptScore W2003165077C74187038 @default.
- W2003165077 hasConceptScore W2003165077C86803240 @default.
- W2003165077 hasConceptScore W2003165077C89423630 @default.
- W2003165077 hasConceptScore W2003165077C98045186 @default.
- W2003165077 hasConceptScore W2003165077C99726746 @default.
- W2003165077 hasIssue "3" @default.
- W2003165077 hasLocation W20031650771 @default.
- W2003165077 hasLocation W20031650772 @default.
- W2003165077 hasLocation W20031650773 @default.
- W2003165077 hasLocation W20031650774 @default.
- W2003165077 hasOpenAccess W2003165077 @default.
- W2003165077 hasPrimaryLocation W20031650771 @default.
- W2003165077 hasRelatedWork W1964288351 @default.
- W2003165077 hasRelatedWork W1989116199 @default.
- W2003165077 hasRelatedWork W2088226047 @default.
- W2003165077 hasRelatedWork W2091869940 @default.
- W2003165077 hasRelatedWork W2295441452 @default.
- W2003165077 hasRelatedWork W2597182293 @default.
- W2003165077 hasRelatedWork W2809351739 @default.
- W2003165077 hasRelatedWork W2812842313 @default.
- W2003165077 hasRelatedWork W2896688061 @default.
- W2003165077 hasRelatedWork W2925167008 @default.
- W2003165077 hasVolume "16" @default.
- W2003165077 isParatext "false" @default.
- W2003165077 isRetracted "false" @default.
- W2003165077 magId "2003165077" @default.
- W2003165077 workType "article" @default.