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- W2003171639 abstract "dl-α-Difluoromethylornithine, an inhibitor of polyamine biosynthesis, was tested for its ability to synchronize Plasmodium falciparum. Asynchronous cultures were pretreated with sorbitol and incubated for 28–30 hr. Then, when cultures consisted of mainly schizont stage parasites, dl-α-difluoromethylornithine was added to the growth medium for another 38–47 hr of incubation. Putrescine was added to parasites arrested at the early trophozoite stage. This resulted in a synchronous resumption of growth. After 19 hr, 83% of parasites were at the schizont stage. After 30 hr, more than 98% of the parasites were in the ring form stage. Furthermore, the transformation of early trophozoites to schizonts occurred within 3 hr, with a slight reduction in parasitemia. Synchrony was maintained for 4–5 biological cycles as confirmed also by flow fluorimetry. It appears that this new approach to synchronize P. falciparum cultures is simple, reproducible, and effective." @default.
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- W2003171639 date "1986-04-01" @default.
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- W2003171639 title "Plasmodium falciparum: Synchronization of cultures with dl-α-difluoromethylornithine, an inhibitor of polyamine biosynthesis" @default.
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- W2003171639 doi "https://doi.org/10.1016/0014-4894(86)90156-6" @default.
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