FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003172914> ?p ?o ?g. }

• W2003172914 abstract "Background: Detecting early infection of chronic hepatitis C (CHC) can prevent late-stage complications including the need for transplant and death. However, screening hepatitis C virus for early detection of the disease has not been found to be beneficial in average risk individuals according to US Food and Drug Administration guidelines. Objectives: The primary aim of this study was to detect infection with hepatitis C antibodies using a rapid immunochromatographic assay in a community setting. The secondary aims included assessment of prevalence rate, disease characteristics and response to the standard treatment. Methods: A screening survey of 13,704 people (0.9% of the population) was conducted from December 2008 through July 2010. It was carried out in three phases involving 4000, 3212 and 6492 average and high risk people. Hepatitis C antibodies were detected using a colloidal gold enhanced rapid immunochromatographic assay. The diagnosis of CHC was confirmed by measuring the viral load using highly sensitive molecular assays. All patients that were detected as having at least stage 1 disease on the liver biopsy were offered standard treatment with pegylated interferon and ribavirin. The complete cost of investigation and treatment was either state funded or supported through governmental charities. Results: 272 (2%) people were detected to have antibodies against hepatitis C virus. 148 subjects (62%) consented for further confirmation of the disease by molecular assays. 69 subjects (70%) agreed to be treated of which 18 were finally excluded due to detection of minimal disease (stage zero) on the liver biopsy. Overall, 78% of patients were detected as having mild disease (stage 1-2) on histology. Of the 51 actually treated with dual antiviral therapy, 37 (72.4%) responded to the treatment and achieved a sustained viral response (SVR). The response rate was found to be superior to the standard of care at present. The screening strategy resulted in six times better the response rate (odds ratio 6.4, p-value 0.002, 95% CI 2.0-20.5). Conclusion: Hepatitis C was detected in 2% of the population using this novel method. A dynamic model (screening) resulted in detection of mild disease with a consequently higher response rate compared to the standard of care." @default.
• W2003172914 created "2016-06-24" @default.
• W2003172914 creator A5018127285 @default.
• W2003172914 creator A5031755512 @default.
• W2003172914 creator A5037763123 @default.
• W2003172914 creator A5038085990 @default.
• W2003172914 creator A5043306214 @default.
• W2003172914 creator A5047800489 @default.
• W2003172914 creator A5049775726 @default.
• W2003172914 creator A5058592111 @default.
• W2003172914 creator A5067086083 @default.
• W2003172914 creator A5069960426 @default.
• W2003172914 creator A5070077987 @default.
• W2003172914 creator A5073311443 @default.
• W2003172914 date "2012-01-01" @default.
• W2003172914 modified "2023-09-22" @default.
• W2003172914 title "Early detection and treatment of chronic hepatitis C in a community-based setting in Doha, Qatar: A dynamic preventive model" @default.
• W2003172914 cites W1995707545 @default.
• W2003172914 doi "https://doi.org/10.5339/qfarf.2012.bmo11" @default.
• W2003172914 hasPublicationYear "2012" @default.
• W2003172914 type Work @default.
• W2003172914 sameAs 2003172914 @default.
• W2003172914 citedByCount "1" @default.
• W2003172914 countsByYear W20031729142013 @default.
• W2003172914 crossrefType "proceedings-article" @default.
• W2003172914 hasAuthorship W2003172914A5018127285 @default.
• W2003172914 hasAuthorship W2003172914A5031755512 @default.
• W2003172914 hasAuthorship W2003172914A5037763123 @default.
• W2003172914 hasAuthorship W2003172914A5038085990 @default.
• W2003172914 hasAuthorship W2003172914A5043306214 @default.
• W2003172914 hasAuthorship W2003172914A5047800489 @default.
• W2003172914 hasAuthorship W2003172914A5049775726 @default.
• W2003172914 hasAuthorship W2003172914A5058592111 @default.
• W2003172914 hasAuthorship W2003172914A5067086083 @default.
• W2003172914 hasAuthorship W2003172914A5069960426 @default.
• W2003172914 hasAuthorship W2003172914A5070077987 @default.
• W2003172914 hasAuthorship W2003172914A5073311443 @default.
• W2003172914 hasConcept C126322002 @default.
• W2003172914 hasConcept C159654299 @default.
• W2003172914 hasConcept C203014093 @default.
• W2003172914 hasConcept C2522874641 @default.
• W2003172914 hasConcept C2775934546 @default.
• W2003172914 hasConcept C2776408679 @default.
• W2003172914 hasConcept C2776455275 @default.
• W2003172914 hasConcept C2776461080 @default.
• W2003172914 hasConcept C2777075537 @default.
• W2003172914 hasConcept C2777766500 @default.
• W2003172914 hasConcept C2779134260 @default.
• W2003172914 hasConcept C2780040827 @default.
• W2003172914 hasConcept C2908647359 @default.
• W2003172914 hasConcept C71924100 @default.
• W2003172914 hasConcept C90924648 @default.
• W2003172914 hasConcept C99454951 @default.
• W2003172914 hasConceptScore W2003172914C126322002 @default.
• W2003172914 hasConceptScore W2003172914C159654299 @default.
• W2003172914 hasConceptScore W2003172914C203014093 @default.
• W2003172914 hasConceptScore W2003172914C2522874641 @default.
• W2003172914 hasConceptScore W2003172914C2775934546 @default.
• W2003172914 hasConceptScore W2003172914C2776408679 @default.
• W2003172914 hasConceptScore W2003172914C2776455275 @default.
• W2003172914 hasConceptScore W2003172914C2776461080 @default.
• W2003172914 hasConceptScore W2003172914C2777075537 @default.
• W2003172914 hasConceptScore W2003172914C2777766500 @default.
• W2003172914 hasConceptScore W2003172914C2779134260 @default.
• W2003172914 hasConceptScore W2003172914C2780040827 @default.
• W2003172914 hasConceptScore W2003172914C2908647359 @default.
• W2003172914 hasConceptScore W2003172914C71924100 @default.
• W2003172914 hasConceptScore W2003172914C90924648 @default.
• W2003172914 hasConceptScore W2003172914C99454951 @default.
• W2003172914 hasLocation W20031729141 @default.
• W2003172914 hasOpenAccess W2003172914 @default.
• W2003172914 hasPrimaryLocation W20031729141 @default.
• W2003172914 hasRelatedWork W2006927772 @default.
• W2003172914 hasRelatedWork W2033989269 @default.
• W2003172914 hasRelatedWork W2041774066 @default.
• W2003172914 hasRelatedWork W2082200384 @default.
• W2003172914 hasRelatedWork W2118320797 @default.
• W2003172914 hasRelatedWork W2132022196 @default.
• W2003172914 hasRelatedWork W2341123991 @default.
• W2003172914 hasRelatedWork W2410716956 @default.
• W2003172914 hasRelatedWork W3181352845 @default.
• W2003172914 hasRelatedWork W4318480679 @default.
• W2003172914 isParatext "false" @default.
• W2003172914 isRetracted "false" @default.
• W2003172914 magId "2003172914" @default.
• W2003172914 workType "article" @default.