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- W2003175040 abstract "d-Galactosamine has been shown to produce a liver damage closely related to human viral hepatitis. d-Galactosamine-1-phosphate and UDP-galactosamine were identified as the predominant early metabolites of galactosamine in rat liver. The conversion of galactosamine-1-phosphate to UDP-galactosamine is shown to be catalyzed by UDP-glucose: α-d-galactose-1-phosphate uridylyltransferase. The low affinity of this enzyme for galactosamine-1-phosphate explains in part the high levels of this compound found in galactosamine treated livers. Under these conditions galactosamine-1-phosphate accumulation is enhanced by the strongly reduced levels of UDPG. Galactosamine-1-phosphate inhibits the UDPG-pyrophosphorylase reaction, the type of inhibition being mainly competitive with glucose-1-phosphate. In the presence of the concentrations of galactosamine-1-phosphate and glucose-1-phosphate found in vivo after galactosamine treatment, UDPG-pyrophosphorylases from rat and calf liver are strongly inhibited in vitro. By these mechanisms galactosamine-1-phosphate counteracts its own conversion to UDP-galactosamine. The influence of the strongly diminished UDPG levels on the UDPG-linked syntheses of glycogen, heteropolysaccharides and glucuronides as well as the trapping of uridine phosphates by formation of UDP-hexosamines may play an important role in the induction of galactosamine hepatitis." @default.
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- W2003175040 date "1969-09-01" @default.
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- W2003175040 title "Studies on the Mechanism of Galactosamine Hepatitis: Accumulation of Galactosamine-1-Phosphate and its Inhibition of UDP-Glucose Pyrophosphorylase" @default.
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- W2003175040 doi "https://doi.org/10.1111/j.1432-1033.1969.tb00677.x" @default.
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