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- W2003180293 abstract "High-dose methotrexate with citrovorum factor rescue (MTX-CF) produced an apparent complete response of the primary tumor in three patients with osteosarcoma. The response was sustained with MTX-CF, intra-arterial cis-diamminedichloroplatinum II (CDP) and Adriamycin (doxorubicin) for 18 months. Treatment was then electively discontinued. Local recurrence occurred in two patients, 6 and 4 months later, respectively. MTX-CF was reinstated and a complete response was again achieved in one patient. This has been maintained for 15+ months with MTX-CF and intra-arterial CDP administered for 13 of the 15+ months. Reinduction with MTX-CF failed in the second relapsed patient but an apparent remission was again achieved with radiation and intra-arterial CDP. This has been maintained with intravenous CDP, cyclophosphamide and phenylalanine mustard for 14+ months. A complete response in the primary tumor was still present in the nonrelapsed patient, 42 months from diagnosis. All patients have remained free of pulmonary metastases, 40+ to 42+ months from diagnosis." @default.
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- W2003180293 date "1985-08-01" @default.
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- W2003180293 title "Control of primary osteosarcoma with chemotherapy" @default.
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- W2003180293 doi "https://doi.org/10.1002/1097-0142(19850801)56:3<461::aid-cncr2820560308>3.0.co;2-l" @default.
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