Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003180593> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2003180593 endingPage "S371" @default.
- W2003180593 startingPage "S367" @default.
- W2003180593 abstract "Successful transplantation of hepatocytes (HC) is hampered by lack of a proper cellular (stromal) and humoral (cytokines) environment at the site of implantation. We have found that another factor responsible for the low survival rate of transplanted HC is their rapid destruction by host granulocytes. In this study we have investigated the mechanism of the rapid elimination of transplanted hepatocytes in a syngeneic and allogeneic recipient. Only 10% of the radioactivity of syngeneic (LEW-LEW) or allogeneic (BN-LEW) HC was recovered in recipient lymphoid tissues 6 h after i.v. infusion. Pretreatment of the recipient with Endoxan or sublethal irradiation brought about an increased accumulation of HC radioactivity in lungs and spleen, indicating the entrament of live cells in these organs. Only a few HC could be seen in the liver 6 h after intraportal infusion. Granulocytes were found to be cytotoxic to HC in vitro (39%). Monoclonal antibodies to class I and II antigens, CD 11/18 and 54, did not block the granulocyte cytotoxicity. Granulocyte and HC cluster formation could be seen on smears from a drop of mixed cultures, the rates of formation increasing with the time of incubation. Two out of 34 monoclonal antibodies to HC surface molecules partly blocked the granulocyte cytotoxicity. No evident differences in the elimination rate and in in vitro cytotoxicity were seen between the syngeneic and allogeneic HC." @default.
- W2003180593 created "2016-06-24" @default.
- W2003180593 creator A5003540119 @default.
- W2003180593 creator A5022769690 @default.
- W2003180593 creator A5026439653 @default.
- W2003180593 creator A5035375805 @default.
- W2003180593 date "1998-06-05" @default.
- W2003180593 modified "2023-09-25" @default.
- W2003180593 title "Hepatocyte transplantation - granulocytes and mononuclear cells recognize the surface of isolated autologous hepatocytes as non-self and destroy them" @default.
- W2003180593 cites W1565398120 @default.
- W2003180593 cites W1969173850 @default.
- W2003180593 cites W1981752846 @default.
- W2003180593 cites W1988471468 @default.
- W2003180593 cites W2020157725 @default.
- W2003180593 cites W2042962210 @default.
- W2003180593 cites W2051465547 @default.
- W2003180593 cites W2063763644 @default.
- W2003180593 cites W2067568507 @default.
- W2003180593 cites W2402018811 @default.
- W2003180593 cites W2411689432 @default.
- W2003180593 cites W2413213837 @default.
- W2003180593 cites W2419152802 @default.
- W2003180593 cites W2653602562 @default.
- W2003180593 cites W3147073273 @default.
- W2003180593 doi "https://doi.org/10.1007/s001470050500" @default.
- W2003180593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9665018" @default.
- W2003180593 hasPublicationYear "1998" @default.
- W2003180593 type Work @default.
- W2003180593 sameAs 2003180593 @default.
- W2003180593 citedByCount "1" @default.
- W2003180593 countsByYear W20031805932015 @default.
- W2003180593 crossrefType "journal-article" @default.
- W2003180593 hasAuthorship W2003180593A5003540119 @default.
- W2003180593 hasAuthorship W2003180593A5022769690 @default.
- W2003180593 hasAuthorship W2003180593A5026439653 @default.
- W2003180593 hasAuthorship W2003180593A5035375805 @default.
- W2003180593 hasConcept C109316439 @default.
- W2003180593 hasConcept C126322002 @default.
- W2003180593 hasConcept C137061746 @default.
- W2003180593 hasConcept C147483822 @default.
- W2003180593 hasConcept C153911025 @default.
- W2003180593 hasConcept C154317977 @default.
- W2003180593 hasConcept C159654299 @default.
- W2003180593 hasConcept C16685009 @default.
- W2003180593 hasConcept C185592680 @default.
- W2003180593 hasConcept C202751555 @default.
- W2003180593 hasConcept C203014093 @default.
- W2003180593 hasConcept C2777983669 @default.
- W2003180593 hasConcept C2780931953 @default.
- W2003180593 hasConcept C2911091166 @default.
- W2003180593 hasConcept C542903549 @default.
- W2003180593 hasConcept C55493867 @default.
- W2003180593 hasConcept C71924100 @default.
- W2003180593 hasConcept C86803240 @default.
- W2003180593 hasConceptScore W2003180593C109316439 @default.
- W2003180593 hasConceptScore W2003180593C126322002 @default.
- W2003180593 hasConceptScore W2003180593C137061746 @default.
- W2003180593 hasConceptScore W2003180593C147483822 @default.
- W2003180593 hasConceptScore W2003180593C153911025 @default.
- W2003180593 hasConceptScore W2003180593C154317977 @default.
- W2003180593 hasConceptScore W2003180593C159654299 @default.
- W2003180593 hasConceptScore W2003180593C16685009 @default.
- W2003180593 hasConceptScore W2003180593C185592680 @default.
- W2003180593 hasConceptScore W2003180593C202751555 @default.
- W2003180593 hasConceptScore W2003180593C203014093 @default.
- W2003180593 hasConceptScore W2003180593C2777983669 @default.
- W2003180593 hasConceptScore W2003180593C2780931953 @default.
- W2003180593 hasConceptScore W2003180593C2911091166 @default.
- W2003180593 hasConceptScore W2003180593C542903549 @default.
- W2003180593 hasConceptScore W2003180593C55493867 @default.
- W2003180593 hasConceptScore W2003180593C71924100 @default.
- W2003180593 hasConceptScore W2003180593C86803240 @default.
- W2003180593 hasIssue "7" @default.
- W2003180593 hasLocation W20031805931 @default.
- W2003180593 hasLocation W20031805932 @default.
- W2003180593 hasOpenAccess W2003180593 @default.
- W2003180593 hasPrimaryLocation W20031805931 @default.
- W2003180593 hasRelatedWork W1990434843 @default.
- W2003180593 hasRelatedWork W1997716688 @default.
- W2003180593 hasRelatedWork W2014258450 @default.
- W2003180593 hasRelatedWork W2038126255 @default.
- W2003180593 hasRelatedWork W2064089409 @default.
- W2003180593 hasRelatedWork W2087539308 @default.
- W2003180593 hasRelatedWork W2126966733 @default.
- W2003180593 hasRelatedWork W2368460920 @default.
- W2003180593 hasRelatedWork W2380360044 @default.
- W2003180593 hasRelatedWork W2443772760 @default.
- W2003180593 hasVolume "11" @default.
- W2003180593 isParatext "false" @default.
- W2003180593 isRetracted "false" @default.
- W2003180593 magId "2003180593" @default.
- W2003180593 workType "article" @default.