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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003181644> ?p ?o ?g. }

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• W2003181644 abstract "An α2A-adrenergic agonist guanfacine improves autonomic imbalance in attention-deficit hyperactivity disorder, suggesting that it may be useful to correct autonomic imbalance in chronic heart failure (CHF) patients. To investigate the effects of guanfacine on cardiac autonomic nerve activities, a microdialysis technique was applied to anesthetized rabbit heart. Acetylcholine (ACh) and norepinephrine (NE) concentrations in atrial dialysates were measured as indices of cardiac autonomic nerve activities. Guanfacine at a dose of 100 μg/kg significantly decreased heart rate and increased dialysate ACh concentration without decreasing sympathetic NE release. Guanfacine may be useful for vagal activation therapy in CHF patients." @default.
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• W2003181644 date "2015-01-01" @default.
• W2003181644 modified "2023-10-16" @default.
• W2003181644 title "Guanfacine enhances cardiac acetylcholine release with little effect on norepinephrine release in anesthetized rabbits" @default.
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• W2003181644 doi "https://doi.org/10.1016/j.autneu.2014.11.010" @default.
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