FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003183006> ?p ?o ?g. }

• W2003183006 endingPage "886" @default.
• W2003183006 startingPage "873" @default.
• W2003183006 abstract "Oncolytic viruses are regulated by the tumor phenotype to replicate and lyse cancer cells selectively. To identify optimal strategies for breast cancer we compared five adenoviruses with distinct regulatory mechanisms: Ad-dl922–947 (targets G1–S checkpoint); Ad-Onyx-015 and Ad-Onyx-017 (target p53/mRNA export); Ad-vKH1 (targets Wnt pathway), and AdEHE2F (targets estrogen receptor/G1–S checkpoint/hypoxic signaling). The quantity of virus required to kill 50% of breast cancer cells after 6 days (EC50, plaque-forming units per cell) was measured. The most potent virus was Ad-dl922–947 (EC50, 0.01–5.4 in SkBr3, MDA-231, MDA-468, MCF7, and ZR75.1 cells), followed by wild-type (Ad-WT; EC50, 0.3–5.5) and AdEHE2F (EC50, 1.4–3.9). Ad-vKH1 (EC50, 7.2–72.1), Ad-Onyx-017 (EC50, 8.4–167), and Ad-Onyx-015 (EC50, 17.7–377) showed less activity. Most viruses showed limited cytotoxicity in normal human cells, including breast epithelium MCF10A (EC50, >722) and fibroblasts (EC50, >192) and only moderate cytotoxicity in normal microvascular endothelial cells (HMVECs; EC50, 42.8–149), except Ad-dl922–947, which was active in HMVECs (EC50, 1.6). After injection into MDA-231 xenografts, Ad-WT, AdEHE2F, and Ad-dl922–947 showed replication, assessed by hexon staining and quantitative polymerase chain reaction measurement of viral DNA, and significantly inhibited tumor growth, leading to extended survival. After intravenous injection Ad-dl922–947 showed DNA replication (233% of the injected dose was measured in liver after 3 days) whereas AdEHE2F did not. Overall, AdEHE2F showed the best combination of low toxicity in normal cells and high activity in breast cancer in vitro and in vivo, suggesting that molecular targeting using estrogen response elements, hypoxia response elements, and a dysregulated G1–S checkpoint is a promising strategy for virotherapy of breast cancer." @default.
• W2003183006 created "2016-06-24" @default.
• W2003183006 creator A5016577781 @default.
• W2003183006 creator A5019534165 @default.
• W2003183006 creator A5023223057 @default.
• W2003183006 creator A5023771695 @default.
• W2003183006 creator A5032131181 @default.
• W2003183006 creator A5048731830 @default.
• W2003183006 creator A5048798659 @default.
• W2003183006 creator A5061778211 @default.
• W2003183006 creator A5075840394 @default.
• W2003183006 creator A5081265349 @default.
• W2003183006 date "2008-09-01" @default.
• W2003183006 modified "2023-10-16" @default.
• W2003183006 title "Comparison of Molecular Strategies for Breast Cancer Virotherapy Using Oncolytic Adenovirus" @default.
• W2003183006 cites W1491631791 @default.
• W2003183006 cites W1567384233 @default.
• W2003183006 cites W1798615689 @default.
• W2003183006 cites W1970718186 @default.
• W2003183006 cites W1971296225 @default.
• W2003183006 cites W1971397865 @default.
• W2003183006 cites W1976177182 @default.
• W2003183006 cites W1990841797 @default.
• W2003183006 cites W1998493765 @default.
• W2003183006 cites W1998605886 @default.
• W2003183006 cites W2001943317 @default.
• W2003183006 cites W2008193013 @default.
• W2003183006 cites W2008890511 @default.
• W2003183006 cites W2010349266 @default.
• W2003183006 cites W2015560811 @default.
• W2003183006 cites W2016080258 @default.
• W2003183006 cites W2018893865 @default.
• W2003183006 cites W2040263952 @default.
• W2003183006 cites W2043400006 @default.
• W2003183006 cites W2056603472 @default.
• W2003183006 cites W2067636446 @default.
• W2003183006 cites W2077282333 @default.
• W2003183006 cites W2078172132 @default.
• W2003183006 cites W2079852426 @default.
• W2003183006 cites W2086579786 @default.
• W2003183006 cites W2090732350 @default.
• W2003183006 cites W2093519391 @default.
• W2003183006 cites W2111772750 @default.
• W2003183006 cites W2114479856 @default.
• W2003183006 cites W2131597845 @default.
• W2003183006 cites W2137961581 @default.
• W2003183006 cites W2143666652 @default.
• W2003183006 cites W2148872113 @default.
• W2003183006 cites W2152617650 @default.
• W2003183006 cites W2153733894 @default.
• W2003183006 cites W2155127143 @default.
• W2003183006 cites W2159813540 @default.
• W2003183006 cites W2160935759 @default.
• W2003183006 cites W2165686484 @default.
• W2003183006 cites W2169503293 @default.
• W2003183006 cites W2313228602 @default.
• W2003183006 cites W2325631985 @default.
• W2003183006 cites W4237815080 @default.
• W2003183006 cites W4246265056 @default.
• W2003183006 doi "https://doi.org/10.1089/hum.2008.047" @default.
• W2003183006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18710328" @default.
• W2003183006 hasPublicationYear "2008" @default.
• W2003183006 type Work @default.
• W2003183006 sameAs 2003183006 @default.
• W2003183006 citedByCount "29" @default.
• W2003183006 countsByYear W20031830062012 @default.
• W2003183006 countsByYear W20031830062013 @default.
• W2003183006 countsByYear W20031830062014 @default.
• W2003183006 countsByYear W20031830062015 @default.
• W2003183006 countsByYear W20031830062022 @default.
• W2003183006 crossrefType "journal-article" @default.
• W2003183006 hasAuthorship W2003183006A5016577781 @default.
• W2003183006 hasAuthorship W2003183006A5019534165 @default.
• W2003183006 hasAuthorship W2003183006A5023223057 @default.
• W2003183006 hasAuthorship W2003183006A5023771695 @default.
• W2003183006 hasAuthorship W2003183006A5032131181 @default.
• W2003183006 hasAuthorship W2003183006A5048731830 @default.
• W2003183006 hasAuthorship W2003183006A5048798659 @default.
• W2003183006 hasAuthorship W2003183006A5061778211 @default.
• W2003183006 hasAuthorship W2003183006A5075840394 @default.
• W2003183006 hasAuthorship W2003183006A5081265349 @default.
• W2003183006 hasConcept C109316439 @default.
• W2003183006 hasConcept C121608353 @default.
• W2003183006 hasConcept C137620995 @default.
• W2003183006 hasConcept C140704245 @default.
• W2003183006 hasConcept C153911025 @default.
• W2003183006 hasConcept C159047783 @default.
• W2003183006 hasConcept C191560914 @default.
• W2003183006 hasConcept C202751555 @default.
• W2003183006 hasConcept C2522874641 @default.
• W2003183006 hasConcept C2777283488 @default.
• W2003183006 hasConcept C2994423619 @default.
• W2003183006 hasConcept C49744831 @default.
• W2003183006 hasConcept C502942594 @default.
• W2003183006 hasConcept C530470458 @default.
• W2003183006 hasConcept C54355233 @default.
• W2003183006 hasConcept C55493867 @default.
• W2003183006 hasConcept C62478195 @default.

• next