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- W2003184511 abstract "The zebrafish golden mutation is characterized by the production of small and irregular-shaped melanin granules, resulting in a lightening of the pigmented lateral stripes of the animal. The recent positional cloning and localization of the golden gene, combined with genotype–phenotype correlations of alleles of its human orthologue (SLC24A5) in African–American and African–Caribbean populations, provide insights into the genetic and molecular basis of human skin colour. SLC24A5 promotes melanin deposition through maturation of the melanosome, highlighting the importance of ion-exchange in the function of this organelle. The zebrafish golden mutation is characterized by the production of small and irregular-shaped melanin granules, resulting in a lightening of the pigmented lateral stripes of the animal. The recent positional cloning and localization of the golden gene, combined with genotype–phenotype correlations of alleles of its human orthologue (SLC24A5) in African–American and African–Caribbean populations, provide insights into the genetic and molecular basis of human skin colour. SLC24A5 promotes melanin deposition through maturation of the melanosome, highlighting the importance of ion-exchange in the function of this organelle." @default.
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- W2003184511 date "2006-09-01" @default.
- W2003184511 modified "2023-09-24" @default.
- W2003184511 title "A golden age of human pigmentation genetics" @default.
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- W2003184511 doi "https://doi.org/10.1016/j.tig.2006.06.010" @default.
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