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• W2003184529 startingPage "350" @default.
• W2003184529 abstract "We have studied the activation of the serum albumin promoter by transcription factor CCAAT/enhancer binding protein-alpha (C/EBP alpha) in the HepG2 hepatoma cell line. We find that three distinct mechanisms determine the ability of C/EBP alpha to activate this promoter in a cell-type-specific and cooperative manner. First, the trans-activating function of C/EBP alpha is generated through cooperation between three separate domains of the protein that we have named trans-activation elements (TE-I through TE-III). The TEs have little or no ability to activate transcription by themselves, but any two can cooperate to do so, both in the C/EBP alpha protein and when linked to the GAL4 DNA-binding domain. Second, TE-III was found to contain a negative regulatory subdomain, the function of which was alleviated when C/EBP alpha was bound in the environment of the albumin promoter. This formed the basis for cooperative activation of this promoter by C/EBP alpha. Finally, we demonstrate that the leucine zipper of C/EBP alpha participates in determining the cell type specificity of albumin promoter activation, as it exerts a strong negative effect on albumin promoter activation in the nonhepatic HeLa cell line but not in HepG2 cells. These findings shed new light on the mode of action of C/EBP alpha and show a novel function for leucine zipper in cell-type-specific gene expression." @default.
• W2003184529 created "2016-06-24" @default.
• W2003184529 creator A5039169149 @default.
• W2003184529 creator A5069425192 @default.
• W2003184529 date "1994-02-01" @default.
• W2003184529 modified "2023-09-25" @default.
• W2003184529 title "Three levels of functional interaction determine the activity of CCAAT/enhancer binding protein-alpha on the serum albumin promoter." @default.
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• W2003184529 doi "https://doi.org/10.1101/gad.8.3.350" @default.
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