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- W2003185047 abstract "Rabbits were injected into the sciatic nerves with either 35S-methionine, or 3H-fucose. After times ranging from 45 min to 15 days the nerves were removed and the total particulate material from the nerves fractionated to give seven subfractions with densities between 0.2 and 1.2 M sucrose. The patterns of radio-labelled proteins were examined by SDS-PAGE and quantitative fluorography. The results showed that the P2 basic protein was metabolically far more active than either the major P0 glycoprotein, or the basic protein BP. The P2 protein also entered the myelin fractions more rapidly than either P0, or BP components. The net synthesis of P0 was slower than P2 and BP and this intrinsic membrane protein remained associated with the denser membrane fractions (>0.7 M sucrose) for longer than the basic proteins prior to entering myelin. Newly synthesized high molecular weight proteins remained concentrated in the denser membrane fractions and turned over faster than the myelin proteins. A low density myelin fraction (B) was detected in which both the P2 protein and certain high molecular weight proteins became more rapidly labelled than in compact myelin. In this fraction the specific activity remained higher than that of compact myelin for up to five days after the injection of 35S-methionine into the nerve. The results indicate that the major PNS myelin proteins are incorporated into and turn over in the various compartments of the Schwann cell plasma membrane—myelin continuum at very different rates." @default.
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- W2003185047 title "The in vivo synthesis of myelin proteins in rabbit sciatic nerve" @default.
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- W2003185047 doi "https://doi.org/10.1016/0197-0186(81)90059-0" @default.
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