FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003186066> ?p ?o ?g. }

• W2003186066 endingPage "2460" @default.
• W2003186066 startingPage "2453" @default.
• W2003186066 abstract "L-Xylulose reductases belong to the superfamily of short chain dehydrogenases and reductases (SDRs) and catalyze the NAD(P)H-dependent reduction of L-xylulose to xylitol in L-arabinose and glucuronic acid catabolism. Here we report the identification of a novel L-xylulose reductase LXR3 in the fungus Trichoderma reesei by a bioinformatic approach in combination with a functional analysis. LXR3, a 31 kDa protein, catalyzes the reduction of L-xylulose to xylitol via NADPH and is also able to convert D-xylulose, D-ribulose, L-sorbose, and D-fructose to their corresponding polyols. Transcription of lxr3 is specifically induced by L-arabinose and L-arabitol. Deletion of lxr3 affects growth on L-arabinose and L-arabitol and reduces total NADPH-dependent LXR activity in cell free extracts. A phylogenetic analysis of known L-xylulose reductases shows that LXR3 is phylogenetically different from the Aspergillus niger L-xylulose reductase LxrA and, moreover, that all identified true L-xylulose reductases belong to different clades within the superfamily of SDRs. This indicates that the enzymes responsible for the reduction of L-xylulose in L-arabinose and glucuronic acid catabolic pathways have evolved independently and that even the fungal LXRs of the L-arabinose catabolic pathway have evolved in different clades of the superfamily of SDRs." @default.
• W2003186066 created "2016-06-24" @default.
• W2003186066 creator A5006250868 @default.
• W2003186066 creator A5033171964 @default.
• W2003186066 creator A5048782041 @default.
• W2003186066 creator A5051190677 @default.
• W2003186066 creator A5070750713 @default.
• W2003186066 creator A5073288256 @default.
• W2003186066 date "2013-03-29" @default.
• W2003186066 modified "2023-09-26" @default.
• W2003186066 title "A Novel <scp>l</scp>-Xylulose Reductase Essential for <scp>l</scp>-Arabinose Catabolism in <i>Trichoderma reesei</i>" @default.
• W2003186066 cites W1577900879 @default.
• W2003186066 cites W1648346008 @default.
• W2003186066 cites W1650184556 @default.
• W2003186066 cites W1848490583 @default.
• W2003186066 cites W1979186118 @default.
• W2003186066 cites W1984169050 @default.
• W2003186066 cites W2005095483 @default.
• W2003186066 cites W2010079335 @default.
• W2003186066 cites W2025494236 @default.
• W2003186066 cites W2026553967 @default.
• W2003186066 cites W2036875488 @default.
• W2003186066 cites W2047804361 @default.
• W2003186066 cites W2048237570 @default.
• W2003186066 cites W2055196793 @default.
• W2003186066 cites W2058911741 @default.
• W2003186066 cites W2075814472 @default.
• W2003186066 cites W2086765625 @default.
• W2003186066 cites W2087096430 @default.
• W2003186066 cites W2090727280 @default.
• W2003186066 cites W2097890276 @default.
• W2003186066 cites W2099249565 @default.
• W2003186066 cites W2110899053 @default.
• W2003186066 cites W2113803821 @default.
• W2003186066 cites W2129123575 @default.
• W2003186066 cites W2138025883 @default.
• W2003186066 cites W2153791416 @default.
• W2003186066 cites W2157844340 @default.
• W2003186066 cites W2159964551 @default.
• W2003186066 cites W4294216491 @default.
• W2003186066 doi "https://doi.org/10.1021/bi301583u" @default.
• W2003186066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3623455" @default.
• W2003186066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23506391" @default.
• W2003186066 hasPublicationYear "2013" @default.
• W2003186066 type Work @default.
• W2003186066 sameAs 2003186066 @default.
• W2003186066 citedByCount "15" @default.
• W2003186066 countsByYear W20031860662013 @default.
• W2003186066 countsByYear W20031860662014 @default.
• W2003186066 countsByYear W20031860662015 @default.
• W2003186066 countsByYear W20031860662016 @default.
• W2003186066 countsByYear W20031860662017 @default.
• W2003186066 countsByYear W20031860662018 @default.
• W2003186066 countsByYear W20031860662020 @default.
• W2003186066 countsByYear W20031860662021 @default.
• W2003186066 countsByYear W20031860662022 @default.
• W2003186066 countsByYear W20031860662023 @default.
• W2003186066 crossrefType "journal-article" @default.
• W2003186066 hasAuthorship W2003186066A5006250868 @default.
• W2003186066 hasAuthorship W2003186066A5033171964 @default.
• W2003186066 hasAuthorship W2003186066A5048782041 @default.
• W2003186066 hasAuthorship W2003186066A5051190677 @default.
• W2003186066 hasAuthorship W2003186066A5070750713 @default.
• W2003186066 hasAuthorship W2003186066A5073288256 @default.
• W2003186066 hasBestOaLocation W20031860661 @default.
• W2003186066 hasConcept C100544194 @default.
• W2003186066 hasConcept C134651460 @default.
• W2003186066 hasConcept C141603559 @default.
• W2003186066 hasConcept C181199279 @default.
• W2003186066 hasConcept C185592680 @default.
• W2003186066 hasConcept C2776084176 @default.
• W2003186066 hasConcept C2776125036 @default.
• W2003186066 hasConcept C2780294150 @default.
• W2003186066 hasConcept C55493867 @default.
• W2003186066 hasConcept C86803240 @default.
• W2003186066 hasConcept C96942376 @default.
• W2003186066 hasConceptScore W2003186066C100544194 @default.
• W2003186066 hasConceptScore W2003186066C134651460 @default.
• W2003186066 hasConceptScore W2003186066C141603559 @default.
• W2003186066 hasConceptScore W2003186066C181199279 @default.
• W2003186066 hasConceptScore W2003186066C185592680 @default.
• W2003186066 hasConceptScore W2003186066C2776084176 @default.
• W2003186066 hasConceptScore W2003186066C2776125036 @default.
• W2003186066 hasConceptScore W2003186066C2780294150 @default.
• W2003186066 hasConceptScore W2003186066C55493867 @default.
• W2003186066 hasConceptScore W2003186066C86803240 @default.
• W2003186066 hasConceptScore W2003186066C96942376 @default.
• W2003186066 hasIssue "14" @default.
• W2003186066 hasLocation W20031860661 @default.
• W2003186066 hasLocation W20031860662 @default.
• W2003186066 hasLocation W20031860663 @default.
• W2003186066 hasLocation W20031860664 @default.
• W2003186066 hasOpenAccess W2003186066 @default.
• W2003186066 hasPrimaryLocation W20031860661 @default.
• W2003186066 hasRelatedWork W1483129018 @default.
• W2003186066 hasRelatedWork W1850986032 @default.
• W2003186066 hasRelatedWork W1965653832 @default.
• W2003186066 hasRelatedWork W2043151771 @default.

• next