FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003186987> ?p ?o ?g. }

• W2003186987 endingPage "6133" @default.
• W2003186987 startingPage "6129" @default.
• W2003186987 abstract "The role of thymic functions in the development of insulin-dependent diabetes was investigated in athymic nude (nu/nu) mice and euthymic heterozygous (+/nu) littermates of BALB/c origin treated with streptozotocin. The injection of a single high dose of streptozotocin (200 mg/kg body weight) induced rapid and permanent hyperglycemia in both nu/nu and +/nu mice. In contrast, the injection of the same total dose divided into multiple subdiabetogenic doses (40 mg/kg per day for 5 consecutive days) caused the development of delayed but progressive hyperglycemia only in the thymus-competent +/nu mice. Female mice of either genotype were significantly less susceptible to streptozotocin at both doses. Restoration of thymic immunity in nu/nu mice by thymus grafts also restored the susceptibility to the hyperglycemic effects of multiple low doses of streptozotocin. Moreover, splenic lymphocytes from +/nu mice previously made diabetic with the multiple low-dose injections of streptozotocin induced transient glucose intolerance in nu/nu mice. The ability of the diabetic spleen cells to transfer the diabetic state was abolished when the splenic lymphocytes were depleted of the T cells but not when they were depleted of B cells. These results provide direct proof that thymus-dependent functions play an obligatory etiologic role in the development of diabetes in mice treated with repeated subdiabetogenic doses of streptozotocin. These observations also add to the growing evidence that autoimmune amplification mechanisms may be critically involved in the etiology of juvenile-onset diabetes mellitus in humans." @default.
• W2003186987 created "2016-06-24" @default.
• W2003186987 creator A5019730885 @default.
• W2003186987 creator A5049316776 @default.
• W2003186987 creator A5062245016 @default.
• W2003186987 date "1980-10-01" @default.
• W2003186987 modified "2023-10-10" @default.
• W2003186987 title "Insulin-dependent diabetes mellitus induced by subdiabetogenic doses of streptozotocin: obligatory role of cell-mediated autoimmune processes." @default.
• W2003186987 cites W1856575346 @default.
• W2003186987 cites W1940736397 @default.
• W2003186987 cites W1943599146 @default.
• W2003186987 cites W1966670737 @default.
• W2003186987 cites W1974089457 @default.
• W2003186987 cites W1983284057 @default.
• W2003186987 cites W1997862692 @default.
• W2003186987 cites W2004073903 @default.
• W2003186987 cites W2010357177 @default.
• W2003186987 cites W2024124393 @default.
• W2003186987 cites W2024530945 @default.
• W2003186987 cites W2033541880 @default.
• W2003186987 cites W2055029884 @default.
• W2003186987 cites W2055680305 @default.
• W2003186987 cites W2062299909 @default.
• W2003186987 cites W2067222441 @default.
• W2003186987 cites W2071224661 @default.
• W2003186987 cites W2088350742 @default.
• W2003186987 cites W2090815691 @default.
• W2003186987 cites W2140655516 @default.
• W2003186987 cites W2143247819 @default.
• W2003186987 cites W2145928261 @default.
• W2003186987 cites W2163818957 @default.
• W2003186987 cites W2340297629 @default.
• W2003186987 cites W2419642161 @default.
• W2003186987 doi "https://doi.org/10.1073/pnas.77.10.6129" @default.
• W2003186987 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/350227" @default.
• W2003186987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6449703" @default.
• W2003186987 hasPublicationYear "1980" @default.
• W2003186987 type Work @default.
• W2003186987 sameAs 2003186987 @default.
• W2003186987 citedByCount "145" @default.
• W2003186987 countsByYear W20031869872012 @default.
• W2003186987 countsByYear W20031869872013 @default.
• W2003186987 countsByYear W20031869872014 @default.
• W2003186987 countsByYear W20031869872015 @default.
• W2003186987 countsByYear W20031869872016 @default.
• W2003186987 countsByYear W20031869872017 @default.
• W2003186987 countsByYear W20031869872018 @default.
• W2003186987 countsByYear W20031869872019 @default.
• W2003186987 countsByYear W20031869872020 @default.
• W2003186987 countsByYear W20031869872021 @default.
• W2003186987 countsByYear W20031869872022 @default.
• W2003186987 crossrefType "journal-article" @default.
• W2003186987 hasAuthorship W2003186987A5019730885 @default.
• W2003186987 hasAuthorship W2003186987A5049316776 @default.
• W2003186987 hasAuthorship W2003186987A5062245016 @default.
• W2003186987 hasBestOaLocation W20031869871 @default.
• W2003186987 hasConcept C126322002 @default.
• W2003186987 hasConcept C134018914 @default.
• W2003186987 hasConcept C203014093 @default.
• W2003186987 hasConcept C2779134260 @default.
• W2003186987 hasConcept C2779280383 @default.
• W2003186987 hasConcept C2779306644 @default.
• W2003186987 hasConcept C2780130043 @default.
• W2003186987 hasConcept C2780931953 @default.
• W2003186987 hasConcept C2781232474 @default.
• W2003186987 hasConcept C555293320 @default.
• W2003186987 hasConcept C71924100 @default.
• W2003186987 hasConcept C8891405 @default.
• W2003186987 hasConceptScore W2003186987C126322002 @default.
• W2003186987 hasConceptScore W2003186987C134018914 @default.
• W2003186987 hasConceptScore W2003186987C203014093 @default.
• W2003186987 hasConceptScore W2003186987C2779134260 @default.
• W2003186987 hasConceptScore W2003186987C2779280383 @default.
• W2003186987 hasConceptScore W2003186987C2779306644 @default.
• W2003186987 hasConceptScore W2003186987C2780130043 @default.
• W2003186987 hasConceptScore W2003186987C2780931953 @default.
• W2003186987 hasConceptScore W2003186987C2781232474 @default.
• W2003186987 hasConceptScore W2003186987C555293320 @default.
• W2003186987 hasConceptScore W2003186987C71924100 @default.
• W2003186987 hasConceptScore W2003186987C8891405 @default.
• W2003186987 hasIssue "10" @default.
• W2003186987 hasLocation W20031869871 @default.
• W2003186987 hasLocation W20031869872 @default.
• W2003186987 hasLocation W20031869873 @default.
• W2003186987 hasLocation W20031869874 @default.
• W2003186987 hasOpenAccess W2003186987 @default.
• W2003186987 hasPrimaryLocation W20031869871 @default.
• W2003186987 hasRelatedWork W1983641721 @default.
• W2003186987 hasRelatedWork W1995071802 @default.
• W2003186987 hasRelatedWork W2003485540 @default.
• W2003186987 hasRelatedWork W2011709829 @default.
• W2003186987 hasRelatedWork W2044988659 @default.
• W2003186987 hasRelatedWork W2055342276 @default.
• W2003186987 hasRelatedWork W2095626059 @default.
• W2003186987 hasRelatedWork W2112457773 @default.
• W2003186987 hasRelatedWork W2131147582 @default.
• W2003186987 hasRelatedWork W2434287781 @default.
• W2003186987 hasVolume "77" @default.

• next