FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003187154> ?p ?o ?g. }

• W2003187154 endingPage "979" @default.
• W2003187154 startingPage "972" @default.
• W2003187154 abstract "Foxp3, a member of the forkhead transcription factor family, is a master gene that controls the development and function of CD4(+)CD25(+) regulatory T (Treg) cells. It is thought to contribute to pathogenesis of many different tumors, including ovarian carcinoma and pancreatic, breast and pancreatic ductal adenocarcinoma. Selectively depleted Foxp3-expressing cells with anit-CD25 antibodies or vaccination of Foxp3 mRNA-transfected dendritic cells engender protective immunity against tumor. This study targeted silencing Foxp3 gene expression using RNA interference (RNAi) delivered by a lentiviral vector to evaluate the therapeutic role of Foxp3 short-hairpin RNAs (shRNAs) in a murine model of leukemia. RLmale symbol1, a mouse CD4(+)CD25(+) leukemia cell with Foxp3 expression, was used as the leukemia animal model. By infecting RLmale symbol1 cells with Lenti-Foxp3-siRNA, we reduced Foxp3 gene expression and the suppressive function of CD4(+)CD25(-) effector cells stimulated with ConA. Moreover, lentiviral-mediated Foxp3 RNAi transduced into RLmale symbol1 cell or injected into the tumor showed suppressive effects on tumor growth and prolonged the survival of tumor-transplanted mice. However, this suppressive effect was abrogated in NOD-SCID mice transplanted with Lenti-Foxp3-siRNA-infected RLmale symbol1 cells. In conclusion, inhibiting Foxp3 gene expression by shRNAs effectively decreases tumor growth of Treg cell-like leukemia. The results may provide a novel strategy for future immunotherapy against cancers." @default.
• W2003187154 created "2016-06-24" @default.
• W2003187154 creator A5008596479 @default.
• W2003187154 creator A5028619959 @default.
• W2003187154 creator A5076608726 @default.
• W2003187154 date "2010-04-01" @default.
• W2003187154 modified "2023-09-26" @default.
• W2003187154 title "Lentiviral-mediated Foxp3 RNAi suppresses tumor growth of regulatory T cell-like leukemia in a murine tumor model" @default.
• W2003187154 cites W1483194800 @default.
• W2003187154 cites W1498187417 @default.
• W2003187154 cites W1533570071 @default.
• W2003187154 cites W1575585006 @default.
• W2003187154 cites W1921702206 @default.
• W2003187154 cites W1985429617 @default.
• W2003187154 cites W1992539503 @default.
• W2003187154 cites W1992641327 @default.
• W2003187154 cites W1995004137 @default.
• W2003187154 cites W1997813173 @default.
• W2003187154 cites W2004708987 @default.
• W2003187154 cites W2013146483 @default.
• W2003187154 cites W2016910978 @default.
• W2003187154 cites W2017642141 @default.
• W2003187154 cites W2019060341 @default.
• W2003187154 cites W2019961165 @default.
• W2003187154 cites W2021611419 @default.
• W2003187154 cites W2034269086 @default.
• W2003187154 cites W2040274110 @default.
• W2003187154 cites W2045812968 @default.
• W2003187154 cites W2049163598 @default.
• W2003187154 cites W2054745099 @default.
• W2003187154 cites W2072671206 @default.
• W2003187154 cites W2074006404 @default.
• W2003187154 cites W2074173132 @default.
• W2003187154 cites W2084545547 @default.
• W2003187154 cites W2097770540 @default.
• W2003187154 cites W2101722758 @default.
• W2003187154 cites W2109351460 @default.
• W2003187154 cites W2110956546 @default.
• W2003187154 cites W2116015828 @default.
• W2003187154 cites W2123149440 @default.
• W2003187154 cites W2134591209 @default.
• W2003187154 cites W2150678612 @default.
• W2003187154 cites W2152678202 @default.
• W2003187154 cites W2153175562 @default.
• W2003187154 cites W2155127143 @default.
• W2003187154 cites W2160117150 @default.
• W2003187154 cites W2160717292 @default.
• W2003187154 cites W2166438464 @default.
• W2003187154 cites W2282749812 @default.
• W2003187154 cites W4235771239 @default.
• W2003187154 cites W4247297474 @default.
• W2003187154 doi "https://doi.org/10.1038/gt.2010.38" @default.
• W2003187154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20357829" @default.
• W2003187154 hasPublicationYear "2010" @default.
• W2003187154 type Work @default.
• W2003187154 sameAs 2003187154 @default.
• W2003187154 citedByCount "11" @default.
• W2003187154 countsByYear W20031871542013 @default.
• W2003187154 countsByYear W20031871542015 @default.
• W2003187154 countsByYear W20031871542016 @default.
• W2003187154 countsByYear W20031871542017 @default.
• W2003187154 countsByYear W20031871542018 @default.
• W2003187154 countsByYear W20031871542022 @default.
• W2003187154 crossrefType "journal-article" @default.
• W2003187154 hasAuthorship W2003187154A5008596479 @default.
• W2003187154 hasAuthorship W2003187154A5028619959 @default.
• W2003187154 hasAuthorship W2003187154A5076608726 @default.
• W2003187154 hasBestOaLocation W20031871541 @default.
• W2003187154 hasConcept C104317684 @default.
• W2003187154 hasConcept C119056186 @default.
• W2003187154 hasConcept C166703698 @default.
• W2003187154 hasConcept C173396325 @default.
• W2003187154 hasConcept C190232843 @default.
• W2003187154 hasConcept C203014093 @default.
• W2003187154 hasConcept C2776090121 @default.
• W2003187154 hasConcept C2778296632 @default.
• W2003187154 hasConcept C2778461978 @default.
• W2003187154 hasConcept C2779727006 @default.
• W2003187154 hasConcept C502942594 @default.
• W2003187154 hasConcept C54355233 @default.
• W2003187154 hasConcept C55493867 @default.
• W2003187154 hasConcept C67705224 @default.
• W2003187154 hasConcept C79484868 @default.
• W2003187154 hasConcept C81885089 @default.
• W2003187154 hasConcept C86803240 @default.
• W2003187154 hasConcept C8891405 @default.
• W2003187154 hasConceptScore W2003187154C104317684 @default.
• W2003187154 hasConceptScore W2003187154C119056186 @default.
• W2003187154 hasConceptScore W2003187154C166703698 @default.
• W2003187154 hasConceptScore W2003187154C173396325 @default.
• W2003187154 hasConceptScore W2003187154C190232843 @default.
• W2003187154 hasConceptScore W2003187154C203014093 @default.
• W2003187154 hasConceptScore W2003187154C2776090121 @default.
• W2003187154 hasConceptScore W2003187154C2778296632 @default.
• W2003187154 hasConceptScore W2003187154C2778461978 @default.
• W2003187154 hasConceptScore W2003187154C2779727006 @default.
• W2003187154 hasConceptScore W2003187154C502942594 @default.
• W2003187154 hasConceptScore W2003187154C54355233 @default.

• next