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- W2003189230 abstract "A total of 54 natural origin compounds were evaluated for their activity in inhibiting the proliferation of glioma cells. Results showed that four Aesculus polyhydroxylated triterpenoid saponins ( 3 – 6 ), six Gleditsia triterpenoid saponins ( 7 – 12 ), and five phenolic compounds ( 43 – 46 , 51 ) had dose-dependent activity suppressing the proliferation of both C6 and U251 cells. Structure–activity relationship analysis suggested that the acetyl group at C-28 for the Aesculus saponins and the monoterpenic acid moiety for the Gleditsia saponins could be critical for the activity of these active compounds. Aesculioside H ( 4 ), gleditsioside A ( 7 ), and feuric acid 3,4-dihydroxyphenethyl ester (FADPE, 46 ) were the three most active compounds from the different types of the active compounds and induced apoptosis and necrosis in glioma cells." @default.
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- W2003189230 date "2014-11-01" @default.
- W2003189230 modified "2023-09-26" @default.
- W2003189230 title "Bioactive triterpenoid saponins and phenolic compounds against glioma cells" @default.
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- W2003189230 doi "https://doi.org/10.1016/j.bmcl.2014.09.087" @default.
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