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- W2003189851 abstract "Significance: The 3-hydroxy-methylglutaryl coenzyme A reductase inhibitors or statins are important therapeutic agents for lowering serum cholesterol levels. However, recent studies suggest that statins may exert atheroprotective effects beyond cholesterol lowering. These so-called “pleiotropic effects” include effects of statins on vascular and inflammatory cells. Thus, it is important to understand whether other signaling pathways that are involved in atherosclerosis could be targets of statins, and if so, whether individuals with “overactivity” of these pathways could benefit from statin therapy, regardless of serum cholesterol level. Recent Advances: Statins inhibit the synthesis of isoprenoids, which are important for the function of the Rho/Rho-associated coiled-coil containing kinase (ROCK) pathway. Indeed, recent studies suggest that inhibition of the Rho/ROCK pathway by statins could lead to improved endothelial function and decreased vascular inflammation and atherosclerosis. Thus, the Rho/ROCK pathway has emerged as an important target of statin therapy for reducing atherosclerosis and possibly cardiovascular disease. Critical Issues: Because atherosclerosis is both a lipid and an inflammatory disease, it is important to understand how inhibition of Rho/ROCK pathway could contribute to statins' antiatherosclerotic effects. Future Directions: The role of ROCKs (ROCK1 and ROCK2) in endothelial, smooth muscle, and inflammatory cells needs to be determined in the context of atherogenesis. This could lead to the development of specific ROCK1 or ROCK2 inhibitors, which could have greater therapeutic benefits with less toxicity. Also, clinical trials will need to be performed to determine whether inhibition of ROCKs, with and without statins, could lead to further reduction in atherosclerosis and cardiovascular disease. Antioxid. Redox Signal. 20, 1251–1267." @default.
- W2003189851 created "2016-06-24" @default.
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- W2003189851 date "2014-03-10" @default.
- W2003189851 modified "2023-10-07" @default.
- W2003189851 title "Rho/Rho-Associated Coiled-Coil Forming Kinase Pathway as Therapeutic Targets for Statins in Atherosclerosis" @default.
- W2003189851 cites W127809968 @default.
- W2003189851 cites W1483473649 @default.
- W2003189851 cites W1537398036 @default.
- W2003189851 cites W1597787921 @default.
- W2003189851 cites W1607892649 @default.
- W2003189851 cites W1965418020 @default.
- W2003189851 cites W1966607170 @default.
- W2003189851 cites W1966687236 @default.
- W2003189851 cites W1967494888 @default.
- W2003189851 cites W1967683969 @default.
- W2003189851 cites W1968661531 @default.
- W2003189851 cites W1971566351 @default.
- W2003189851 cites W1972392712 @default.
- W2003189851 cites W1972718914 @default.
- W2003189851 cites W1974941580 @default.
- W2003189851 cites W1975232532 @default.
- W2003189851 cites W1975247881 @default.
- W2003189851 cites W1976103123 @default.
- W2003189851 cites W1976581024 @default.
- W2003189851 cites W1980123375 @default.
- W2003189851 cites W1982283178 @default.
- W2003189851 cites W1985383424 @default.
- W2003189851 cites W1986886732 @default.
- W2003189851 cites W1987806705 @default.
- W2003189851 cites W1988190448 @default.
- W2003189851 cites W1988475719 @default.
- W2003189851 cites W1992190451 @default.
- W2003189851 cites W1993379452 @default.
- W2003189851 cites W1994294460 @default.
- W2003189851 cites W1995498107 @default.
- W2003189851 cites W1997087774 @default.
- W2003189851 cites W2000007398 @default.
- W2003189851 cites W2000060365 @default.
- W2003189851 cites W2001953889 @default.
- W2003189851 cites W2004191401 @default.
- W2003189851 cites W2004535997 @default.
- W2003189851 cites W2005515164 @default.
- W2003189851 cites W2006830036 @default.
- W2003189851 cites W2008548958 @default.
- W2003189851 cites W2011107835 @default.
- W2003189851 cites W2016921709 @default.
- W2003189851 cites W2016955748 @default.
- W2003189851 cites W2017033872 @default.
- W2003189851 cites W2017315346 @default.
- W2003189851 cites W2018223916 @default.
- W2003189851 cites W2019619408 @default.
- W2003189851 cites W2020043339 @default.
- W2003189851 cites W2021090126 @default.
- W2003189851 cites W2022816128 @default.
- W2003189851 cites W2031450490 @default.
- W2003189851 cites W2032022098 @default.
- W2003189851 cites W2032295238 @default.
- W2003189851 cites W2033055236 @default.
- W2003189851 cites W2033554531 @default.
- W2003189851 cites W2035834791 @default.
- W2003189851 cites W2036272929 @default.
- W2003189851 cites W2036787121 @default.
- W2003189851 cites W2037654515 @default.
- W2003189851 cites W2039358229 @default.
- W2003189851 cites W2041075406 @default.
- W2003189851 cites W2042928998 @default.
- W2003189851 cites W2047294292 @default.
- W2003189851 cites W2052034057 @default.
- W2003189851 cites W2053788014 @default.
- W2003189851 cites W2055545486 @default.
- W2003189851 cites W2057139885 @default.
- W2003189851 cites W2061600983 @default.
- W2003189851 cites W2064533570 @default.
- W2003189851 cites W2064951452 @default.
- W2003189851 cites W2065874222 @default.
- W2003189851 cites W2066963386 @default.
- W2003189851 cites W2067236087 @default.
- W2003189851 cites W2070013537 @default.
- W2003189851 cites W2070346980 @default.
- W2003189851 cites W2071124826 @default.
- W2003189851 cites W2076444878 @default.
- W2003189851 cites W2077080652 @default.
- W2003189851 cites W2077342384 @default.
- W2003189851 cites W2077603983 @default.
- W2003189851 cites W2077792958 @default.
- W2003189851 cites W2077834462 @default.
- W2003189851 cites W2078603028 @default.
- W2003189851 cites W2078616546 @default.
- W2003189851 cites W2081245863 @default.
- W2003189851 cites W2085728170 @default.
- W2003189851 cites W2086242462 @default.
- W2003189851 cites W2087537846 @default.
- W2003189851 cites W2089014953 @default.
- W2003189851 cites W2089750661 @default.
- W2003189851 cites W2090041633 @default.
- W2003189851 cites W2091193879 @default.