Matches in SemOpenAlex for { <https://semopenalex.org/work/W200319174> ?p ?o ?g. }
- W200319174 endingPage "55" @default.
- W200319174 startingPage "143" @default.
- W200319174 abstract "Bioprosthetic cardiac valve calcification is a frequent complication after long-term valve replacement. In this study the authors sought to examine the biologic determinants of this type of dystrophic calcification using subcutaneous implants of glutaraldehyde-preserved porcine aortic valve leaflets (GPVs) in rats. GPVs and clinical valvular bioprostheses were prepared identically. Retrieved implants were examined for calcification and the deposition of osteocalcin (OC), a vitamin K-dependent, bone-derived protein, that is found in other dystrophic and ectopic calcifications. GPVs implanted in 3-week-old rats calcified progressively (GPV Ca2+, 122.9 +/- 6.0 micrograms/mg) after 21 days, with mineral deposition occurring in a morphologic pattern comparable to that noted in clinical retrievals. Calcified GPVs accumulated osteocalcin (OC, 183.4 +/- 19.4 ng/mg); Nonpreserved porcine aortic leaflet implants did not calcify (Ca2+ + 5.6 +/- 1.0 micrograms/mg). Millipore diffusion chamber (0.45-mu pore size enclosed GPV implants accumulated calcium and adsorbed osteocalcin despite the absence of attached host cells. GPVs implanted for 21 days in 8-month-old rats calcified less (GPV Ca2+, 22.4 +/- 5.0 micrograms/mg) than did GPVs implanted in 3-week-old rats (see above). High-dose warfarin therapy (80 mg/kg) did not alter GPV calcification (GPV Ca2+, 39.6 +/- 2.9 micrograms/mg) in 72-hour subcutaneous implants in 3-week-old male rats, compared with control rats (GPV Ca2+, 40.8 +/- 4.8 micrograms/mg)." @default.
- W200319174 created "2016-06-24" @default.
- W200319174 creator A5031768147 @default.
- W200319174 creator A5041792509 @default.
- W200319174 creator A5070312971 @default.
- W200319174 creator A5075204223 @default.
- W200319174 creator A5082379813 @default.
- W200319174 creator A5083085835 @default.
- W200319174 date "1983-11-01" @default.
- W200319174 modified "2023-10-17" @default.
- W200319174 title "Biologic determinants of dystrophic calcification and osteocalcin deposition in glutaraldehyde-preserved porcine aortic valve leaflets implanted subcutaneously in rats." @default.
- W200319174 cites W135037860 @default.
- W200319174 cites W1501315399 @default.
- W200319174 cites W1543715150 @default.
- W200319174 cites W1605030605 @default.
- W200319174 cites W1961022724 @default.
- W200319174 cites W1968636052 @default.
- W200319174 cites W1968822620 @default.
- W200319174 cites W1971465791 @default.
- W200319174 cites W1978953330 @default.
- W200319174 cites W1981348266 @default.
- W200319174 cites W1982502919 @default.
- W200319174 cites W1986733889 @default.
- W200319174 cites W1993430905 @default.
- W200319174 cites W1999296922 @default.
- W200319174 cites W2001348404 @default.
- W200319174 cites W2006033468 @default.
- W200319174 cites W2012371141 @default.
- W200319174 cites W2012895535 @default.
- W200319174 cites W2016610145 @default.
- W200319174 cites W2018321225 @default.
- W200319174 cites W2025347997 @default.
- W200319174 cites W2043627567 @default.
- W200319174 cites W2043868853 @default.
- W200319174 cites W2050093383 @default.
- W200319174 cites W2054451237 @default.
- W200319174 cites W2059692836 @default.
- W200319174 cites W2065707622 @default.
- W200319174 cites W2066730611 @default.
- W200319174 cites W2079517119 @default.
- W200319174 cites W2083892795 @default.
- W200319174 cites W2085850205 @default.
- W200319174 cites W2087451742 @default.
- W200319174 cites W2092717233 @default.
- W200319174 cites W2096326108 @default.
- W200319174 cites W2097993282 @default.
- W200319174 cites W2099434333 @default.
- W200319174 cites W2128342505 @default.
- W200319174 cites W2133365994 @default.
- W200319174 cites W2155956743 @default.
- W200319174 cites W2157069319 @default.
- W200319174 cites W2157274342 @default.
- W200319174 cites W2160300792 @default.
- W200319174 cites W2161209070 @default.
- W200319174 cites W2171706260 @default.
- W200319174 cites W2332173182 @default.
- W200319174 cites W2414246197 @default.
- W200319174 cites W2414649865 @default.
- W200319174 cites W2415474358 @default.
- W200319174 cites W2423167066 @default.
- W200319174 cites W2437118829 @default.
- W200319174 cites W80053532 @default.
- W200319174 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1916380" @default.
- W200319174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6605687" @default.
- W200319174 hasPublicationYear "1983" @default.
- W200319174 type Work @default.
- W200319174 sameAs 200319174 @default.
- W200319174 citedByCount "88" @default.
- W200319174 countsByYear W2003191742012 @default.
- W200319174 countsByYear W2003191742013 @default.
- W200319174 countsByYear W2003191742014 @default.
- W200319174 countsByYear W2003191742015 @default.
- W200319174 countsByYear W2003191742016 @default.
- W200319174 countsByYear W2003191742017 @default.
- W200319174 countsByYear W2003191742019 @default.
- W200319174 countsByYear W2003191742020 @default.
- W200319174 countsByYear W2003191742021 @default.
- W200319174 countsByYear W2003191742022 @default.
- W200319174 countsByYear W2003191742023 @default.
- W200319174 crossrefType "journal-article" @default.
- W200319174 hasAuthorship W200319174A5031768147 @default.
- W200319174 hasAuthorship W200319174A5041792509 @default.
- W200319174 hasAuthorship W200319174A5070312971 @default.
- W200319174 hasAuthorship W200319174A5075204223 @default.
- W200319174 hasAuthorship W200319174A5082379813 @default.
- W200319174 hasAuthorship W200319174A5083085835 @default.
- W200319174 hasConcept C126322002 @default.
- W200319174 hasConcept C131075544 @default.
- W200319174 hasConcept C134018914 @default.
- W200319174 hasConcept C141071460 @default.
- W200319174 hasConcept C142724271 @default.
- W200319174 hasConcept C160160445 @default.
- W200319174 hasConcept C181199279 @default.
- W200319174 hasConcept C185592680 @default.
- W200319174 hasConcept C2775930297 @default.
- W200319174 hasConcept C2780309369 @default.
- W200319174 hasConcept C2780714102 @default.
- W200319174 hasConcept C2780814755 @default.