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• W2003192177 abstract "As part of our studies of selectin blockers, we prepared 1-deoxy-3'-O-sulfo LeX analogs (1-3), 1-deoxy-3'-O-phosphono LeX analogs (4), and 1-deoxy sLeX analogs (5-7), and examined their inhibitory activities against natural ligand (sLeX) binding to E-selectin, P-selectin, and L-selectin. The 1-deoxy sLeX 5 was up to 20 times more potent an inhibitor than the sLeX tetrasaccharide toward P- and L-selectin binding. This indicates that the modification of the 1 or 2 position of sLeX is useful in the design of a more potent selectin blocker." @default.
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• W2003192177 date "1996-03-15" @default.
• W2003192177 modified "2023-09-27" @default.
• W2003192177 title "Studies on Selectin Blocker. 1. Structure−Activity Relationships of Sialyl Lewis X Analogs" @default.
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• W2003192177 doi "https://doi.org/10.1021/jm9506478" @default.
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