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- W2003193521 abstract "Recombinant activated factor VII (rFVIIa) is currently licensed in the United States for treatment of bleeding episodes in patients with deficiencies of factor VIII (FVIII) or IX (FIX) who are refractory to factor replacement because of circulating inhibitors. A 1999 report of its successful use to stop what was deemed to be lethal hemorrhage after an abdominal gunshot wound in a young soldier without pre-existing coagulopathy has prompted exploration of other uses for rFVIIa. The virtual explosion of proposed uses of rFVIIa raises issues not only regarding our understanding of the coagulation system, but also regarding its efficacy, cost-effectiveness, and safety." @default.
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- W2003193521 date "2005-07-01" @default.
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- W2003193521 title "Emerging Off-Label Uses for Recombinant Activated Factor VII: Grading the Evidence" @default.
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- W2003193521 doi "https://doi.org/10.1016/j.ccc.2005.04.001" @default.
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